Nutrition and Bone Health
          Golaleh Asghari, PhD
     Nutrition and Endocrine Research Center
  Let’s Discuss
  • Peak bone mass
  • Calcium and vitamin D
  • Other nutrients and dietary factors
  • Bone loss
  • Osteoporosis  
     Peak Bone Mass
     • Bone strength reflects the integration of bone mineral density 
       (BMD) and other properties of bone that are collectively called 
       "bone quality".
     • BMD in adults is determined by peak bone mass and subsequent 
       bone loss.
     • In one analysis, for every one standard deviation decrease in BMD 
       at the hip, there was a 2.6-fold increase in the risk of hip fracture. 
     • Thus, the prevention of low bone mass is directed to maximizing 
       peak bone mass and minimizing the rate of bone loss, with the 
       ultimate goals of maintaining bone strength and preventing 
       fractures. 
     Osteoporosis prevention, diagnosis, and therapy. JAMA; 2001.
     Marshall D et al; BMJ; 1996.
    Peak Bone Mass (cont.)
    The statement of Professor Charles Dent:
          “Osteoporosis is a pediatric disease” 
        the importance of achieving the maximum 
      potential peak bone mass, thereby attenuating 
            the effects of bone loss later in life.
    Dent CE; Proceedings of the International Symposium on Clinical Aspects of Metabolic Bone Disease; 1973.
    Peak Bone Mass (cont.)
    • Peak bone mass: 
       “the maximum bone mass achieved in life” 
    • Interventions to optimize peak bone mass 
       should be directed toward a healthy lifestyle 
       during the bone-forming years, particularly 
       adolescence. 
    • These can be divided into categories of:
        –Nutrition
        –Physical activity
        –Other lifestyle factors
      E Michael Lewiecki; Prevention of osteoporosis; 2019.