PATHWAYS ADDITIONAL REFERENCES  
                 NOT IN MAGAZINE: Fall 2016 
      Clinical	Perspective	
      Lipedema:	Abnormal	Female	Fat	that	Just	Won’t	Go	Away		
      By	Dr.	Karen	Herbst	and	Natalie	Munguia	 
      Primary	References	
      1.	Herbst	KL.	Rare	adipose	disorders	(RADs)	masquerading	as	obesity.	Acta	Pharmacol	Sin	2012;33:155-72.	doi:	
      10.1038/aps.2011.153.		
      	
      2.	Szel	E,	Kemeny	L,	Groma	G,	Szolnoky	G.	Pathophysiological	dilemmas	of	lipedema.	Med	Hypotheses	
      2014;83:599-606.	doi:	10.1016/j.mehy.2014.08.011.	Epub		Aug	23.		
      	
      3.	Wold	LE,	Hines	EA,	Jr.,	Allen	EV.	Lipedema	of	the	legs;	a	syndrome	characterized	by	fat	legs	and	edema.	Ann	
      Intern	Med	1951;34:1243-50.		
      	
      References	 	
      1.	Herbst	K,	Mirkovskaya	L,	Bharhagava	A,	Chava	Y,	Te	CH.	Lipedema	Fat	and	Signs	and	Symptoms	of	Illness,	
      Increase	with	Advancing	Stage.	Archives	of	Medicine	2015;7:1-8.		
      	
      2.	Martin	JM,	Monteagudo	C,	Montesinos	E,	Guijarro	J,	Llombart	B,	Jorda	E.	Lipedematous	scalp	and	
      lipedematous	alopecia:	a	clinical	and	histologic	analysis	of	3	cases.	J	Am	Acad	Dermatol	2005;52:152-6.		
      	
      3.	Wold	LE,	Hines	EA,	Jr.,	Allen	EV.	Lipedema	of	the	legs;	a	syndrome	characterized	by	fat	legs	and	edema.	Ann	
      Intern	Med	1951;34:1243-50.		
      	
      4.	Szel	E,	Kemeny	L,	Groma	G,	Szolnoky	G.	Pathophysiological	dilemmas	of	lipedema.	Med	Hypotheses	
      2014;83:599-606.	doi:	10.1016/j.mehy.2014.08.011.	Epub		Aug	23.		
      	
      5.	Wold	LE,	Hines	EA,	Jr.,	Allen	EV.	Lipedema	of	the	legs;	a	syndrome	characterized	by	fat	legs	and	edema.	Ann	
      Intern	Med	1951;34:1243-50.		
      	
      6.	Suga	H,	Araki	J,	Aoi	N,	Kato	H,	Higashino	T,	Yoshimura	K.	Adipose	tissue	remodeling	in	lipedema:	adipocyte	
      death	and	concurrent	regeneration.	J	Cutan	Pathol	2009;3:3.		
      	
      7.	Rapprich	S,	Baum	S,	Kaak	I,	Kottmann	T,	Podda	M.	Treatment	of	lipoedema	using	liposuction.	Results	of	our	
      own	surveys.	Phlebologie	2015;44:121-32.		
      	
      8.	Schneider	M,	Conway	EM,	Carmeliet	P.	Lymph	makes	you	fat.	Nat	Genet	2005;37:1023-4.		
      	
      9.	Szolnoky	G,	Borsos	B,	Barsony	K,	Balogh	M,	Kemeny	L.	Complete	decongestive	physiotherapy	with	and	
      without	pneumatic	compression	for	treatment	of	lipedema:	a	pilot	study.	Lymphology	2008;41:40-4.		
      	
      10.	Witte	CL,	Witte	MH.	Contrasting	patterns	of	lymphatic	and	blood	circulatory	disorders.	Lymphology	
      1987;20:171-8.		
      	
      11.	Erlich	C,	Iker	E,	Herbst	KL,	Kahn	LA,	Sears	DD,	Kenyon	M.	Lymphedema	and	Lipedema	Nutrition	
      Guide.		Foods,	vitamins,	minerals,	and	supplements.	San	Francisco:	Lymph	Notes;	2015.		
      	
      12.	Westfall	TC,	Westfall	DP.	Adrenergic	Agonists	and	Antagonists.	In:	Brunton	LL,	Lazo	JS,	Parker	KL,	eds.	
      Goodman	and	Gilman's	The	Pharmacological	Basis	of	Therapeutics,	eleventh	edition.	New	York:	McGraw-Hill	
      Medical	Publishing	Division;	2006:237-95.		
      	
      13.	Boudet	C,	Peyrin	L.	Comparative	effect	of	tropolone	and	diosmin	on	venous	COMT	and	sympathetic	activity	
      in	rat.	Arch	Int	Pharmacodyn	Ther	1986;283:312-20.		
      	
      14.	Kuppusamy	UR,	Das	NP.	Potentiation	of	beta-adrenoceptor	agonist-mediated	lipolysis	by	quercetin	and	
      fisetin	in	isolated	rat	adipocytes.	Biochem	Pharmacol	1994;47:521-9.		
      	
      15.	Marcelon	G,	Vanhoutte	PM.	Mechanism	of	action	of	Ruscus	extract.	International	Angiology	1984;3,	
      Supplement	1:74-6.		
      	
      16.	Bouskela	M.	Microcirculatory	responses	to	Ruscus	extract	in	the	hamster	cheek	pouch.	In:	Vanhoute	PM,	
      ed.	Return	Circulation	and	Norepinephrine:	An	Update.	Paris,	France:	John	Libby	Eurotext;	1991:207-18.		
      	
      17.	Scallan	JP,	Hill	MA,	Davis	MJ.	Lymphatic	vascular	integrity	is	disrupted	in	type	2	diabetes	due	to	impaired	
      nitric	oxide	signalling.	Cardiovasc	Res	2015;107:89-97.	doi:	10.1093/cvr/cvv117.	Epub	2015	Apr	7.		
      	
      18.	Gulati	OP.	Pycnogenol(R)	in	chronic	venous	insufficiency	and	related	venous	disorders.	Phytother	Res	
      2014;28:348-62.	doi:	10.1002/ptr.5019.	Epub	2013	Jun	15.		
      	
      19.	Berti	F,	Omini	C,	Longiave	D.	The	mode	of	action	of	aescin	and	the	release	of	prostaglandins.	Prostaglandins	
      1977;14:241-9.		
      	
      20.	Yu	Z,	Su	P.	Effect	of	beta-aescin	extract	from	Chinese	buckeye	seed	on	chronic	venous	insufficiency.	
      Pharmazie	2013;68:428-30.		
      	
      21.	Conley	SM,	Bruhn	RL,	Morgan	PV,	Stamer	WD.	Selenium's	effects	on	MMP-2	and	TIMP-1	secretion	by	
      human	trabecular	meshwork	cells.	Invest	Ophthalmol	Vis	Sci	2004;45:473-9.		
      	
      22.	Rutkowski	JM,	Boardman	KC,	Swartz	MA.	Characterization	of	lymphangiogenesis	in	a	model	of	adult	skin	
      regeneration.	American	journal	of	physiology	Heart	and	circulatory	physiology	2006;291:H1402-H10.		
      	
      23.	Nourollahi	S,	Mondry	TE,	Herbst	KL.	Bucher’s	Broom	and	Selenium	Improve	Lipedema:	A	Retrospective	Case	
      Study	Alternative	and	Integrative	Medicine	2013;2:1-7.		
      	
      24.	Micke	O,	Bruns	F,	Schäfer	U,	Kisters	K,	Hesselmann	S,	Willich	N.	Selenium	in	the	treatment	of	acute	and	
      chronic	lymphedema.	Trace	Elements	and	Electrolytes	2000;17:206-9.		
      	
      25.	Laclaustra	M,	Navas-Acien	A,	Stranges	S,	Ordovas	JM,	Guallar	E.	Serum	selenium	concentrations	and	
      diabetes	in	U.S.	adults:	National	Health	and	Nutrition	Examination	Survey	(NHANES)	2003-2004.	Environ	Health	
      Perspect	2009;117:1409-13.	doi:	10.289/ehp.0900704.	Epub	2009	May	15.		
      26.	Macdonald	JM,	Sims	N,	Mayrovitz	HN.	Lymphedema,	lipedema,	and	the	open	wound:	the	role	of	
      compression	therapy.	Surg	Clin	North	Am	2003;83:639-58.		
      	
      27.	Shin	NR,	Lee	JC,	Lee	HY,	et	al.	An	increase	in	the	Akkermansia	spp.	population	induced	by	metformin	
      treatment	improves	glucose	homeostasis	in	diet-induced	obese	mice.	Gut	2014;63:727-35.	doi:	10.1136/gutjnl-
      2012-303839.	Epub	2013	Jun	26.		
      	
      28.	Bannister	CA,	Holden	SE,	Jenkins-Jones	S,	et	al.	Can	people	with	type	2	diabetes	live	longer	than	those	
      without?	A	comparison	of	mortality	in	people	initiated	with	metformin	or	sulphonylurea	monotherapy	and	
      matched,	non-diabetic	controls.	Diabetes	Obes	Metab	2014;16:1165-73.	doi:	10.11/dom.12354.	Epub	2014	Jul	
      31.		
      	
      29.	Stewart	JA,	Cochrane	DJ,	Morton	RH.	Differential	effects	of	whole	body	vibration	durations	on	knee	
      extensor	strength.	J	Sci	Med	Sport	2009;12:50-3.	Epub	2007	Dec	19.		
      	
      30.	Witte	CL,	Witte	MH,	Unger	EC,	et	al.	Advances	in	Imaging	of	Lymph	Flow	Disorders.	RadioGraphics	
      2000;20:1697–719.		
      	
      31.	Dietzel	R,	Reisshauer	A,	Jahr	S,	Calafiore	D,	Armbrecht	G.	Body	composition	in	lipoedema	of	the	legs	using	
      Dual-Energy-X-Ray-Absorptiometry	-	a	case	control	study.	Br	J	Dermatol	2015;1:13697.		
      	
      32.	Fonder	MA,	Loveless	JW,	Lazarus	GS.	Lipedema,	a	frequently	unrecognized	problem.	J	Am	Acad	Dermatol	
      2007;57:S1-3.		
      	
      33.	Partsch	H,	Stoberl	C,	Urbanek	A,	Wenzel-Hora	BI.	Clinical	use	of	indirect	lymphography	in	different	forms	of	
      leg	edema.	Lymphology	1988;21:152-60.		
      	
      34.	Stutz	JJ,	Krahl	D.	Water	jet-assisted	liposuction	for	patients	with	lipoedema:	histologic	and	
      immunohistologic	analysis	of	the	aspirates	of	30	lipoedema	patients.	Aesthetic	Plast	Surg	2009;33:153-62.	doi:	
      10.1007/s00266-008-9214-y.	Epub	2008	Jul	29.		
      	
      35.	Hattori	J,	Yamakage	M,	Seki	S,	Okazaki	K,	Namiki	A.	Inhibitory	effects	of	the	anesthetics	propofol	and	
      sevoflurane	on	spontaneous	lymphatic	vessel	activity	in	rats.	Anesthesiology	2004;101:687-94.		
      	
      36.	Pollock	H,	Forman	S,	Pollock	T,	Raccasi	M.	Conscious	sedation/local	anesthesia	in	the	office-based	surgical	
      and	procedural	facility.	Clin	Plast	Surg	2013;40:383-8.	doi:	10.1016/j.cps.2013.04.014.	Epub		May	23.		
      	
      37.	Foldi	E,	Foldi	M.	Lipedema.	In:	Foldi	M,	Foldi	E,	eds.	Foldi's	Textbook	of	Lymphology.	Munich,	Germany:	
      Elsevier	GmbH;	2006:417-27.		
      	
      38.	Herbst	KL.	Rare	adipose	disorders	(RADs)	masquerading	as	obesity.	Acta	Pharmacol	Sin	2012;33:155-72.	
      doi:	10.1038/aps.2011.153.	
      	            	
      Clinical	Perspective	
      Taking	Care	of	Your	Lower	Limbs		
      By	Gurdish	Sandhu	 
      References	
      	
      1.	Foot	Problems:	Lifestyle	&	Management.	Aging	&	Health	A	to	Z.	Last	modified	March	2012.	
      http://www.healthinaging.org/aging-and-health-a-to-z/topic:foot-problems/info:lifestyle-and-management/		
      	
      2.	Olson,	Jim.	Foot	Care	for	Older	Adults	(Health	1241).	Vancouver:	Vancouver	Community	College,	2004.			
      	
      3.	Taking	Care	of	Your	Toes.	Foot	Care	for	Lower	Extremity	Lymphedema.	Last	modified	November	14,	
      2011.	http://www.lymphedemapeople.com/wiki/doku.php?id=foot_care_for_lymphedema		
      	
      Additional	References	
      	
      http://www.health.harvard.edu/staying-healthy/foods-that-fight-inflammation	
      https://draxe.com/anti-inflammatory-foods/