Tablet Manufacturing
                Lecture 4
              Industrial Pharmacy
                   th
                  5 class
                 st
                 1 semester
  The manufacture of granulations for tablet
  compression may follow one or a combination
  of three established methods:
        Direct compression
      Compression granulation
         Wet granulation. 
 Table 1. processing steps commonly required with each
 technique.
      Processing step                   Wet           Dry           Direct 
      Raw materials (API + Excipients)  x             x             x
      weighing                          x             x             x
      Mixing                            x             x             x
      Compression (slugging)                          x
      Granulation (wet mass)            x
      Screening (sieve # 8-12)          x
      Drying (< 60 °C)                  x
      Screening (sieve # 20-25)         x             x             x
      Mixing                            x             x
      Compression                       x             x             x
                             1.    Direct compression
                There are a few crystalline substances, such as sodium
                chloride, that may be compressed directly.
                Notes: 1- The vast majority of medicinal agents
                are rarely so easy to tablet.
                2- Compression of a single substance may
                producetabletsthatdonotdisintegrate.
                          Other components are needed 
                 Interfere with the compressibility of the active 
                                       ingredient 
                     Minimize the usefulness of the method.