Contents
   Introduction. Nutritional genomics
   Nutrigenetics
   Nutritional epigenomics
   Nutrigenomics
   Nutrigenomics tools: present and future
                       Nutritional genomics
      Interactions genes - nutrients
         survival and reproduction
                                           NUTRIGENETICS
                                           NUTRIGENETICS
                               NUTRITIONAL 
                               NUTRITIONAL              NUTRIGENOMICS
                               EPIGENOMICS              NUTRIGENOMICS
                               EPIGENOMICS
                                Nutrigenetics
     • Genetic changes influence the response to nutrients
     Example
     Example
                       reduce incidence of cancer         Polymorphism at codon 198
                                                        Substitution of proline to leucine
                                                      Pro/Pro
                                                      Pro/Leu          80%
                                                                             greater risk of 
                                                                             lung cancer
                                                        Leu/Leu          130%
                      Nutritional epigenetics
                       Nutritional epigenetics
     • Nutrients cause modifications in the genome that don’t 
         involve changes in the DNA sequence
     Example
     Example
                                                                      Vitamins B12, B6, niacin, 
       Methylated DNA          gene expression is silenced            riboflavin and minerals
        Nutrients  involved in DNA methylation                               SAM for 
                                                                             genome 
                                                                           methylation
                                                                      Nutritional deficiencies   
                                                                    alter methylation patterns
                                                                  Alteration of gene expression
            Nutrigenomics
            Nutrigenomics
   • Nutrients influence gene expression, mainly through 
    transcriptions factors (TFs)