Powders as a primary requirement for 
    Powders as a primary requirement for 
      pharmaceutical dosage form.
      pharmaceutical dosage form.
                INTRODUCTION
 •   Definition: Preformulatoin study is defined as 
     investigation of physical and  Chemical properties of a 
     drug and mixture of drug and excipient.
 •   Goal of preformulation: The major goal of 
     preformulatoin is to gather data, Which will permit the 
     rational development of safe and efficacious dosage 
     form..
 •   Preformulation also helps in formulating new dosage 
     form of already existing drug.
                                      PREFORMULATION
 •   DRUG DISCOVERY                                             Formulation            
                    BRIDGE             &Development
 •    In short , by preformulation one can determine the best 
     suitable dosage form for the drug molecule.
       HYGROSCOPICITY:-
         CONTENTS :-
  A.  INTRODUCTION
  B. METHOD OF DETERMINATION
  C. IMPORTANCE OF MEASUREMENT
  D. METHOD OF IMPROVEMENT 
 (A)INTRODUCTION :
  Hygroscopicity: - It is the tendency of 
  material to absorb moisture from 
  atmosphere & get dynamic equilibrium 
  with water in the atmosphere.
 Deliquescent: - It is the hygroscopic 
  substance which absorb moisture from air 
  and they can be liquefied by partially 
  or wholly forming solution.
 Efflorescent: - a substance which loses 
  water to form a lower hydrate or become 
  anhydrous is termed as efflorescent.
 (B) METHOD  OF  DETERMINATION :
 • To carry out study, sample of compound are 
  accurately weighed into container and placed at 
  various humid condition for period of upto 2 
  weeks.
   If Weight gain –  Deliquescent or Hygroscopic
   If Weight loss –  Efflorescent 
 • Also determined by TGA, GC, & KF titration 
 • Versaperm has deviced a WVTR meter that can 
  measure the permeability of package to 
  moisture.so that humidity can be accurately 
  controlled.