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picture1_Chemical Equilibrium Ppt 66965 | Powder Rheologyhygrocompaction


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File: Chemical Equilibrium Ppt 66965 | Powder Rheologyhygrocompaction
powders as a primary requirement for powders as a primary requirement for pharmaceutical dosage form pharmaceutical dosage form introduction definition preformulatoin study is defined as investigation of physical and chemical ...

icon picture PPTX Filetype Power Point PPTX | Posted on 28 Aug 2022 | 3 years ago
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    Powders as a primary requirement for 
    Powders as a primary requirement for 
      pharmaceutical dosage form.
      pharmaceutical dosage form.
                INTRODUCTION
 •   Definition: Preformulatoin study is defined as 
     investigation of physical and  Chemical properties of a 
     drug and mixture of drug and excipient.
 •   Goal of preformulation: The major goal of 
     preformulatoin is to gather data, Which will permit the 
     rational development of safe and efficacious dosage 
     form..
 •   Preformulation also helps in formulating new dosage 
     form of already existing drug.
                                      PREFORMULATION
 •   DRUG DISCOVERY                                             Formulation            
                    BRIDGE             &Development
 •    In short , by preformulation one can determine the best 
     suitable dosage form for the drug molecule.
       HYGROSCOPICITY:-
         CONTENTS :-
  A.  INTRODUCTION
  B. METHOD OF DETERMINATION
  C. IMPORTANCE OF MEASUREMENT
  D. METHOD OF IMPROVEMENT 
 (A)INTRODUCTION :
  Hygroscopicity: - It is the tendency of 
  material to absorb moisture from 
  atmosphere & get dynamic equilibrium 
  with water in the atmosphere.
 Deliquescent: - It is the hygroscopic 
  substance which absorb moisture from air 
  and they can be liquefied by partially 
  or wholly forming solution.
 Efflorescent: - a substance which loses 
  water to form a lower hydrate or become 
  anhydrous is termed as efflorescent.
 (B) METHOD  OF  DETERMINATION :
 • To carry out study, sample of compound are 
  accurately weighed into container and placed at 
  various humid condition for period of upto 2 
  weeks.
   If Weight gain –  Deliquescent or Hygroscopic
   If Weight loss –  Efflorescent 
 • Also determined by TGA, GC, & KF titration 
 • Versaperm has deviced a WVTR meter that can 
  measure the permeability of package to 
  moisture.so that humidity can be accurately 
  controlled.                                                   
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...Powders as a primary requirement for pharmaceutical dosage form introduction definition preformulatoin study is defined investigation of physical and chemical properties drug mixture excipient goal preformulation the major to gather data which will permit rational development safe efficacious also helps in formulating new already existing discovery formulation bridge short by one can determine best suitable molecule hygroscopicity contents b method determination c importance measurement d improvement it tendency material absorb moisture from atmosphere get dynamic equilibrium with water deliquescent hygroscopic substance air they be liquefied partially or wholly forming solution efflorescent loses lower hydrate become anhydrous termed carry out sample compound are accurately weighed into container placed at various humid condition period upto weeks if weight gain loss determined tga gc kf titration versaperm has deviced wvtr meter that measure permeability package so humidity controlle...

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