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picture1_Standard Deviation Ppt 66720 | Icpdetectionlimitssera6


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File: Standard Deviation Ppt 66720 | Icpdetectionlimitssera6
detection limit dl or limit of detection lod the detection limit is the concentration that is obtained when the measured signal differs significantly from the background calculated by this equation ...

icon picture PPTX Filetype Power Point PPTX | Posted on 27 Aug 2022 | 3 years ago
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         Detection Limit (DL) or
            Limit of Detection (LOD)
         The detection limit is the concentration that is obtained when 
           the measured signal differs significantly from the background.
         Calculated by this equation for the ARCOS.
         C = concentration of the high sample
            1
         C = concentration of the blank
            0
         I  = raw intensity of the high sample (cps)
            1
         I = raw intensity of the blank (cps)
            0 
         3 is a confidence factor
         σ (sigma) = standard deviation from a number of 
           measurements of the blank  (cps)
         Confidence Factor - Example
          Black curve – probability density function for the normal distribution of blank measurements.
          LOD (Limit of detection) – defined here as 3 times the standard deviation of the blank.
           α – alpha error (probability of a false positive) is only 1%.
           β – beta error (probability of a false negative) - there is a 50% chance that the sample could contain 
            the element, but record it as less than the LOD.
          LOQ (Limit of quantification) – defined here as 10 times the standard deviation - a minimal chance of a 
           false negative or a false positive.  Gives greater confidence that the reported values are actually 
           quantifiable.
          Example for P177.495 -
               using 2 measurements
                                                      Sample   Type  P 177.495
                                                                     cps
                                                     Blank         1      331.526
             C = 20 ppm                                             2      308.626
                1 
                                                                        320.076
          
             C = 0 ppm                                         sd           16.192
                2 
                                                               rsd           5.059
                                                     20 ppm        1       171326
             I = 171777 cps
               1 
                                                                    2       172227
                                                                        171777
             I  = 320 cps
               0
                                                               sd          637.103
                                                              rsd           0.371
              
                                      OR
                                                    or ~0.019 
                                                    ppm
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...Detection limit dl or of lod the is concentration that obtained when measured signal differs significantly from background calculated by this equation for arcos c high sample blank i raw intensity cps a confidence factor sigma standard deviation number measurements example black curve probability density function normal distribution defined here as times alpha error false positive only beta negative there chance could contain element but record it less than loq quantification minimal gives greater reported values are actually quantifiable p using type ppm sd rsd...

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