Table F-1. Cannabis RCTs study characteristics
                                                                                               Crossover 
            PMID                                         Author, Year         Study Design     Design           Setting
            16282192                                     Blake, 2006          RCT              No               Europe
            33118602                                     Chaves, 2020         RCT              No               Brazil
            27720917                                     de Vries, 2017       RCT              No               Europe
            32770831                                     Eibach, 2020         RCT              Yes              Europe
            18182416                                     Frank, 2008          RCT              Yes              Europe
            23180178                                     Langford, 2013       RCT              No               Europe
            23742737                                     Lynch, 2014          RCT              Yes              Canada
            17997224                                     Nurmikko, 2007       RCT              No               Europe
            23070400                                     Pini, 2012           RCT              Yes              Europe
             20855984                                        Rintala, 2010          RCT               Yes                U.S.
             16186518                                        Rog, 2005              RCT               No                 Europe
             29073592                                        Schimrigk, 2017        RCT               No                 Europe
             19808912                                        Selvarajah, 2010       RCT               No                 Europe
             24420962                                        Serpell, 2014          RCT               No                 Europe
             17974490                                        Skrabek, 2008          RCT               No                 Canada
             22921260                                        Toth, 2012             RCT               No                 Canada
             25288189                                        Turcotte, 2015         RCT               No                 Canada
             16988792                                        Wissel, 2006           RCT               Yes                Germany
             31793418                                        Xu, 2020               RCT               No                 U.S.
             22791906                                        Zajicek, 2012          RCT               No                 Europe
      Abbreviations: CBD = cannabidiol; HIV = human 
      immunodeficiency virus; NA = not applicable; 
      NPP = neuropathic pain; NR = not reported; 
      RCT = randomized controlled trial; THC = 
      tetrahydrocannabinol; U.S. = United States 
                                                               Age Measure 
              Pain Population       Pain Condition             (Mean, Median) Age, Years         Female %         Race, White %
              Inflammatory arthritis Rheumatoid arthritis      Mean              63              79               NR
              Fibromyalgia          Fibromyalgia               Mean              52              100              NR
                                    Chronic pancreatitis and 
                                    postsurgical abdominal 
              Visceral pain         pain                       Mean              53              50               96
              NPP                   HIV-associated             Mean              50              3                NR
              NPP                   NR                         Mean              50              23               NR
              NPP                   Multiple sclerosis         Mean              49              68               98
                                    Chemotherapy-induced 
              NPP                   neuropathic pain           Mean              56              83               NR
              NPP                   Mixed                      Mean              53              59               NR
                                    Medication overuse 
              Headache              headache                   Mean              53              67               NR