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the market analysis of antidandruff agents in ukraine alla nemchenko viktoriya nazarkina vitoriia mishchenko sergiy timofeyev maria podkolzina alla lebedyn national pharmaceutical university department of economics of pharmacy kharkiv ukraine ...

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                           The market analysis of antidandruff agents in Ukraine 
                           Alla Nemchenko, Viktoriya Nazarkina,  Viкtoriia Mishchenko*, Sergiy Timofeyev, Maria 
                           Podkolzina, Alla Lebedyn 
                            National Pharmaceutical University, Department of Economics of Pharmacy, Kharkiv, Ukraine. 
                           Correspondence: Victoriia Ivanovna Mishchenko, Department of Economics of Pharmacy, National University of Pharmacy, Kharkiv, Ukraine, 4, Valentinivska Street, 
                           61121, Ukraine. E-mail: viktoriamischenko @ ukr.net 
                           ABSTRACT 
                            
                           The analysis of domestic market of antiseborrheic medicated products has been conducted. A range of products of medicinal cosmetics, 
                           parapharmaceutical products, antidandruff agents of domestic and foreign production registered in Ukraine has been analyzed in terms 
                           of active substances and drug forms, as well as their affordability. In the analysis, the data of the State Register of Medicines, price lists 
                           and official sources of the specialized information were used. According to the ATC classification, most drugs (55%) referred to 
                           derivatives of imidazole and triazole and contain ketoconazole in their composition (D01A C08). The number of antidandruff 
                           medicines registered in Ukraine was 7% of the total number of the products analyzed. Among the products of medicinal cosmetics 
                           with the antiseborrheic action, 50% of the range were consisted of domestic cosmetic agents based on plant extracts. Antiseborrheic 
                           medicated products and products of medicinal cosmetics in the form of shampoos have been represented at the pharmaceutical market 
                           most widely. According to the results of the study, it has been determined that drugs for treating dandruff mainly included antifungal 
                           drugs (ketoconazole, selenium disulfide, terbinafine), keratolytics (salicylic acid, sulfur), keratinization regulators (zinc pyrithione) in 
                           their composition. 
                           Keywords: dandruff, drugs, marketing analysis, parapharmaceutical products, products of medicinal cosmetics, seborrhea. 
                            
                                                                                                                                                                                complex scientifically based approach to be solved [5, 6]
                           Introduction                                                                                                                                                                                                                                                      . 
                                                                                                                                                                                At the same time, one of the key elements is the settlement of 
                           Dandruff (Lat. pityriasis – bran) has often been considered as a                                                                                     the issue of the official status for parapharmaceutical products 
                           cosmetic defect, and at the same time, it is the manifestation of                                                                                    (PP) and products of medicinal cosmetics (PMC) in Ukraine. 
                           a number of dermatological diseases, such as seborrheic                                                                                              According to the current legislation (the Order of the Ministry 
                                                                                                                 [1, 2]
                           dermatitis, psoriasis, pityriasis versicolor                                                  . In recent years,                                     of Health of Ukraine dated 06.07.2012 №. 498 as amended by 
                           there have been high growth rates in the market of antidandruff                                                                                      the order of the Ministry of Health of Ukraine dated 
                           agents (both cosmetic and therapeutic); and it has been                                                                                              23.11.2015 № 764), the list of goods that can be purchased and 
                           explained not only by an objective necessity due to the                                                                                              sold by pharmacies and their structural subdivisions has been 
                           prevalence of the disease, but also by extensive advertising. The                                                                                    expanded. In recent years, on the shelves of pharmacies there 
                           unsystematic and uncontrolled self-treatment is often                                                                                                has been a large variety of therapeutic shampoos created taking 
                           ineffective and can lead to serious consequences [3, 4]
                                                                                                                                     . Thus, this                               into account the characteristics of dandruff, and the type and 
                           problem is both cosmetic and medical; moreover, it requires a                                                                                        the condition of hair (dry, normal, oily, painted, etc.). In most 
                                                                 Access this article online                                                                                     cases, the treatment should be prescribed by a specialist-
                                                                                                                                                                                trichologist or dermatologist. 
                                     Website: www.japer.in                                               E-ISSN: 2249-3379                                                      Some shampoos and cosmetics that contain medicinal substances 
                                                                                                                                                                                (for example, ketoconazole, zinc pyrithione), but are not 
                                                                                                                                                                                officially registered in the State Register of Medicines, can be 
                           How to cite this article: Alla Nemchenko, Viktoriya Nazarkina, Viкtoriia                                                                             sold not only in pharmacies, but also in supermarkets, shops, 
                           Mishchenko, Sergiy Timofeyev, Maria Podkolzina, Alla Lebedyn. The market                                                                             markets; however, in this case, they have to meet other 
                           analysis of antidandruff agents in Ukraine. J Adv Pharm Edu Res 2019;9(2):75-                                                                        requirements [7] .
                           81.                                                                                                                                                                                  .  
                           Source of Support: Nil, Conflict of Interest: None declared. 
                           This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-Non Commercial-
                           ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is 
                           given and the new creations are licensed under the identical terms. 
                             © 2019 Journal of Advanced Pharmacy Education & Research | Published by SPER Publication                                    75 
                            
                                                Alla Nemchenko et al.: The market analysis of antidandruff agents in Ukraine 
               The aim of the work was to analyze the market of therapeutic                       •    oily seborrhea is characterized by the increased oiliness 
               and preventive antidandruff products sold in pharmacies of                              of hair and scalp due to hyperfunction of the sebaceous 
               Ukraine in order to provide the effective and controlled                                glands, as well as yellow scales of dandruff; 
               dandruff correction and prevention [7].
                                                                                                  •    mixed seborrhea – simultaneous manifestation of dry 
                                                                                                       and oily seborrhea on different parts of the head [2, 10]
               Materials and Methods                                                                                                                            . 
               The market analysis of antiseborrheic products was conducted.                   Dandruff should be treated differentially. To obtain a reliable 
               In the study, the data of the State Register of Medicines, papers               effect, it is important to have a correct diagnosis from a doctor, 
               in scientific journals, price lists and information from the official           know the causes of the disease, and choose the appropriate set 
               websites of manufacturers and distributors of products of                       of measures. As a rule, the duration of treatment is 3-6 weeks. 
               medicinal cosmetics, and the range of pharmacies in Kharkiv                     Modern methods of seborrhea treatment have been based on 
               were used. The methods of comparison, as well as logical,                       the data confirming its fungal origin. When the scalp shampoos 
               mathematical and statistical methods were applied.                              containing ketoconazole, zinc, and tar are prescribed at least 
                                                                                               twice a week to eliminate the manifestations of seborrhea, their 
               Results and Discussion                                                          use should be not less than a month. Furthermore, these 
                                                                                               products can be used as preventive ones. In severe diseases 
               Seborrhea is a common dermatological disease that affects the                   characterized by the presence of lesions with a marked 
               scalp; its characteristic manifestation is inflammation and flaking             inflammation and dense layering of scales before using 
               of the skin (dandruff). Numerous clinical and laboratory studies                antifungal drugs, it is necessary to apply exfoliating products 
               have confirmed that the main cause of seborrheic dermatitis of                  (salicylic acid, tar preparations) or to soften the scales with oils, 
               the scalp and dandruff are yeast-like fungi –Malassezia furfur                  and then use a shampoo with ketoconazole. In the most severe 
               (Pityrosporum ovale), which are permanent inhabitants of the skin               cases, hormonal ointments are locally prescribed, and antifungal 
               of a healthy person. Under unfavorable conditions for the                       drugs are orally administered (ketoconazole, terbinafine, 
               organism (stress, hormonal imbalance, chronic diseases,                         fluconazole). The complex therapy includes vitamins, anti-
               thermal effects), the protective function of the skin is disturbed;             allergic medicines, and drugs for normalization of the 
               as a result, the opportunistic pathogenic microflora is activated               gastrointestinal tract. Measures against dandruff also include 
               and intensely proliferated causing dandruff [8, 9]                              normalization of the diet and the water-salt balance restoration. 
                                                                 .                             The  physiotherapeutic procedures, such as cryomassage with 
               There are the following types of seborrheic dermatitis:                         liquid nitrogen and darsonvalization of the scalp skin, are also 
                  •    dry seborrhea develops as the skin and hair dryness, a                  recommended [5, 9, 10]
                       lot of dandruff and severe itching caused by                                                  . 
                       hypofunction of the sebaceous glands of the scalp;                      Currently, all antidandruff agents sold in pharmacies have been 
                                                                                               conventionally divided into four groups (Figure 1) [7, 11]
                                                                                                                                                          . 
                             I Antimycotics (ketoconazole, climbazole) – inhibit            II Antifungals (cyclopirox, zinc pyrithione, octopirox) 
                           development of fungi, improve the hair growth (Nizoral,             – affect fungi (Sebiprox, Stiprox, Freederm Zink);
                                        Perkhotal, Ketozoral®-Darnitsa)
                                                                                  Antidandruff 
                                                                                      agents
                                                                                            IV Anti-inflammatory agents and revitalisants (plant 
                            III Exfoliating agents (sulfur, salicylic acid) – provide         extracts, essential oils) – stabilize the process of cell 
                             removal of dandruff scales from the scalp (Sulsena);           division, sooth irritation and itching, contribute to pore 
                                                                                              contraction, reduce the activity of sebaceous glands 
                                                                                                                    (Algopix)
                                                                                                                                                             
                                                                 Figure 1. Classification of antidandruff agents 
                                                                                           
               As a result of the analysis of the nomenclature of antidandruff                     •  keratolytics (salicylic acid, papain, glycolic acid, 
               agents by the composition of active substances, it has been                             keluamide);  
               found that the main active ingredients were:                                        •  keratinization regulators (zinc pyrithione, selenium 
                   •  antifungal and antimycotic drugs (ketoconazole,                                  disulfide, octopirox, cyclopirox, ichthyol, tar, sulfur);  
                       terbinafine, clotrimazole, climbazole, miconazole,                          •  cytostatic drugs (selenium disulfide, zink);  
                       cyclopiroxolamine);                                                         •  antipruritic drugs (extracts of medicinal plants); 
               76                                                                         Journal of Advanced Pharmacy Education & Research  | Apr-Jun 2019 | Vol 9 | Issue 2               
                
                                                      Alla Nemchenko et al.: The market analysis of antidandruff agents in Ukraine 
                      •  anti-inflammatory agents (essential oils,                                                              Clear antidandruff shampoo 
                          cyclopiroxolamine) [11, 12]
                                                         .                                                                       and conditioner for men,        Unilever, Ukraine 
                                                                                                                                      deep cleansing 
                 At the same time, the products of medicinal cosmetics                                                           Estel BHL 61 antidandruff 
                 presented at the market can have a mono-component                                                                   shampoo 250 ml             LLC “Unicosmetic” 
                 composition and the targeted action (Table 1) or contain a 
                 complex of active ingredients and, consequently, a wide range                                                     Fitoval Regular Care 
                 of action (Table 2).                                                                                             Antidandruff Shampoo            КРКА, Slovenia 
                                                                                                                                     Formula, 200 ml 
                  
                   Table 1: The analysis of monocomponent products for the                                                         Fitoval Intensive Care 
                       treatment of dandruff by the composition of active                                                         Antidandruff Shampoo            КРКА, Slovenia 
                                                                                                                                     Formula, 100 ml 
                                                 substances                                                                     Freederm Zink antidandruff 
                     Composition     The name and the drug form      Manufacturer, country                                     shampoo for dry hair 150 ml     Mipharm S.p.A., Italy 
                                     Antifungal and antimycotic drugs 
                             Dermazol® shampoo, 20 mg/ml, 50 ml or        Kusum Healthcare                                         Ducray Squanorm dry 
                                    100 ml, in vials, sachet, 8 ml         Pvt. Ltd., India                                     dandruff hair shampoo, 200     Ducray Lab., Freance 
                                                                                                                                            ml 
                            Ketozoral®-Darnitsa shampoo, 20 mg/g, 60  Darnitsa, Ukraine 
                                          g, 100 g, in vials                                                                     Freederm tar antidandruff 
                                                                         Pharma International                                   shampoo for oily hair, 150     Mipharm S.p.A., Italy 
                              Kenazol® shampoo, 2%, 100 ml, in vials            Jordan                                                      ml 
                            Nizoral® shampoo, 20 mg/g, 25 ml, 60 ml,       McNeil Products                                      TL “Home Doctor” “Tar + 
                                             in bottles                        Limited                                          tea tree” antidandruff cream    RPA “Elfa”, Ukraine 
                                                                                                                                       paste, 150 ml 
                             Ebersept shampoo, 60 ml, 120 ml, in vials     Bros Ltd, Greece 
                       ole                                                                                                       Recipes of Grandmother 
                       z       Sebozol antidandruff shampoo, 100 ml           Dionis, RF                              r
                       ona                                                                                            Ta         Agafia. Black antidandruff    Natura Siberica, Russia 
                       toc   Antidandruff shampoo with ketoconazole,                                                                 shampoo, 350 ml 
                       Ke                     100 ml                     RPA “Elfa”, Ukraine 
                                                                                                                                 ENJEE tar hair shampoo,      Beauty and health. Ltd., 
                              Antidandruff shampoo with ketoconazole       LLC “Aromat”,                                                  250 ml                      Ukraine 
                                              100 ml                           Ukraine                                              “Elfa Horse line” tar 
                               Biocon “Strength of Hair” antidandruff           Biocon                                          antidandruff shampoo, 200       RPA “Elfa”, Ukraine 
                                          shampoo 150 ml                                                                                    ml 
                             “Horse Power” antidandruff shampoo with                                                                Sulsena antidandruff 
                                     ketoconazole, 250 ml vial             LLC “LekoPro”                                             shampoo, 150 ml 
                            Denon antidandruff, antifungal and hair loss                                                            Sulsena antidandruff 
                                                                           ZEE Lab., India                            e          preventive paste, 1% and      “Amalgameluxe” Ltd., 
                                         shampoo, 100 ml                                                              id
                                                                                                                      f
                                                                                                                      l
                                                                                                                      u              2%, 40 ml, 75 ml                 Ukraine 
                                                                                                                      is
                     o   ne        Sebiprox shampoo, 1%, 60 ml           Stiefel Lab., Ireland                         d
                     ir  i                                                                                            m
                     p   m                                                                                            iu
                     o
                     l       Stiprox antidandruff therapeutic shampoo,                                                n         Sulsena antidandruff peeling 
                                                                                                                      e
                     yc                                                  Stiefel Lab., Ireland                        l
                     C   xola                                                                                         e              shampoo, 150 ml 
                                           1.5%, 100 ml                                                               S
                                                                                                                                VICHY Dercos antidandruff 
                       ne     Terbinakod shampoo and shower gel for                                                                                           Cosmetic Active Intern., 
                       i
                       f                                                PhytoBioTechnologies                                     shampoo for dry hair, 200 
                       na      prevention of dandruff and seborrheic                                                                                                   France 
                       i                                                                                                                    ml 
                       b                                                    Ltd., Ukraine 
                       r                 dermatitis, 200 ml 
                       Te                                                                                   
                                                 Keratolytics                                              Multicomponent antidandruff agents are aimed at solving a set 
                           
                          c                                                                                of problems, namely the improvement of the epidermal barrier 
                          i    
                          yl  id         CM Ultrasensitive gel 
                          c   c
                          i
                          l   a                                       RPA “Elfa”, Ukraine                  state, cleansing the scalp and hair from skin pells, oily skin and 
                          a
                          S                shampoo, 400 ml                                                 hair reduction, and reduction of itching and skin sensitivity. The 
                                         Keratinization regulators                                         use of the complex of plant extracts and essential oils of 
                                     Skin-cap aerosol, 0.2%, 100  Cheminova Internacional                  cypress, juniper, rosemary, eucalyptus, tea tree has been rather 
                                         ml, in monoblock can             S.A., Spain                      effective since they have the antifungal, anti-inflammatory and 
                            one                                                                            antipruritic effect, and inhibit the division of keratinocytes [5, 13] 
                            i         Nature. MED. antidandruff 
                            th                                                                             (Table 2). 
                            i                                     Georg BioSystems, Ukraine 
                            r
                            y         shampoo for men, 200 ml 
                             p                                                                              
                            nc        Clear antidandruff shampoo 
                            Zi                                                                              
                                         for women, oily scalp         Unilever, Ukraine                    
                                                balance 
                 Journal of Advanced Pharmacy Education & Research  | Apr-Jun 2019 | Vol 9 | Issue 2                                                                         77 
                  
                                                           Alla Nemchenko et al.: The market analysis of antidandruff agents in Ukraine 
                   Table 2: The analysis of complex products for the treatment                                                               Insight antidandruff cleansing shampoo, 
                                                     of dandruff                                                                                      1000 ml (ELEY, Italy) 
                      Composition               The name and the drug form                  Action 
                                                                                              l,                       Hemp oil, clove,      Cannaderm Capillus antiseborrheic hair 
                    Selenium disulfide  VICHY Dercos antidandruff shampoo for                 a                                                  shampoo, 150 ml (Simply You 
                                          normal and oily hair, 200 ml (Cosmetic              ung                         grapefruit                  Pharmaceuticals A.S) 
                     and salicylic acid                                                       f   c
                                               Active Internationale, France)                 nti ti                                                                                             
                                                                                              , a toly                                                                                          nt,
                                                                                              c   a                   Piroctone olamine                                                         e
                     Zinc pyrithione,                                                         ti  r                                       Kallos Med Detox antidandruff shampoo for 
                                                                                              ta  e
                                          Alphakeptol D.S. antidandruff shampoo                   k                       salicylic acid,                                                       olli
                    piroctone olamine                                                         tos                                              oily hair and scalp, 1000 ml (Kallos             m
                                          (Laboratoire Dermophil Indien, France)                                        horsetail, lemon                                                        e
                       salicylic acid                                                         Cy                                                      Cosmetics, Hungary)                       , 
                                                                                                                          balm, nettle                                                          y    
                                                                                                                                                                                                tor c
                                          Dermazol plus shampoo, 50 ml, 100 ml                                                                                                                  a   ti
                                                                                                                                                                                                m   i
                                            vials (Kusum Healthcare Pvt. Ltd.)                                                                                                                  m   ur
                   Ketoconazole, zinc                                                                                                                                                           a
                                                                                                                      Piroctone olamine                                                         l   pr
                                                                                                                                                                                                nf
                       pyrithione           Keto plus shampoo, 60 ml, 150 ml                                                                                                                    i   nti
                                                                                                                           fir, nettle,       Natura Siberica NS antidandruff hair              -   a
                                                     (Glenmark; India)                                                    chamomile,       shampoo, 400 ml (Natura Siberica, Russia)            nti
                                                                                                                                                                                                l, a
                                                                                                                      wormwood,                                                                 a
                                         Eucerin DermoCapillare antidandruff gel                                                    junipe                                                      ung
                    Piroctone olamine                                                           c                                                                                               f
                                        shampoo for oily scalp, 250 ml (Beiersdorf              ti                                                                                              nti
                        climbazole                                                              ta                   Piroctone olamine,      DUCRAY Squanorm oily dandruff hair                 A
                                                       AG, Germany)                             tos                      glycolic acid                  shampoo, 200 ml 
                                                                                                y
                                                                                                c
                                                                                                , 
                                                                                                c
                                                                                                i                                                                                                    
                                          Ducray Kertyol P.S.O. Keratoreducing                  t                                                                                               ,   e
                                                                                                                                                                                                c   v
                                                                                                                                             TL “Green Pharmacy”. “Birch buds and               i   i
                                                                                                                                                                                                t   t
                                                  Cream, 100 ml (France)                        toly                  Piroctone olamine                                                         i   a
                                                                                                a                                                                                               ur
                                                                                                r                                           castor oil” antidandruff shampoo, 350 ml                er
                                                                                                e                    birch buds, castor o                                                       pr  en
                                        Ducray Selegel dry dandruff shampoo, 125                l, k                                                  (RPA “Elfa”, Ukraine)                     nti eg
                      Salicylic acid,                                                           a                                                                                               A   r
                  cyclopiroxolamine,       ml (Pierre Fabre Dermo-Cosmetique,                   ung
                                                                                                f
                     zinc pyrithione                       France)                              nti                    Tar and salicylic      Algopix antidandruff shampoo, 200 g                  
                                                                                                A                                                                                                 c
                                                                                                                             acid                    (Medica АТ, Bulgaria)                        ti
                                          Kallos KJMN antidandruff shampoo 1 L                                                                                                                    toly
                                                                                                                                                                                                  a
                                               (Kallos Cosmetics, Hungary)                                                                 Pharma Bio tar antidandruff shampoo, 200               r
                                                                                                                        Sulfur  and tar                                                           Ke
                                                                                                                                                ml (Alliance of beauty, Ukraine) 
                     Climbazole and  Zinovit antidandruff and anti-inflammatory                                                                                                                    
                                                                                                                                                                                                  l
                                        shampoo, 150 ml (ZAO Zelenaya Dubrava,                                       Sulphide1% + Saw  “Elfa” Sulsen_forte antidandruff shampoo,                  a
                     zinc pyrithione                       Russia)                                                                           2%, for oily hair, 150 ml (RPA “Elfa”,               ung
                                                                                                                         Palmetto1%                                                               f
                                        Bio Pharma Burdock antidandruff shampoo,                                                                             Ukraine)                             nti
                                                                                                                                                                                                  A
                                           200 ml (Alliance of beauty, Ukraine)                                                                                                                    
                                                                                                                                                                                                  l
                                                                                                                        Sulphide1% +       “Elfa” Sulsen_forte antidandruff shampoo,              a
                                          Klorane dry dandruff shampoo with the                                                            2%, for normal and dry hair, 150 ml (RPA               ung
                                       extract of Nasturtium, 200 ml (Pierre Fabre                                      Aminotein1%                                                               f
                                                                                                                                                         “Elfa”, Ukraine)                         nti
                                                   Lab. Klorane, France)                                                                                                                          A
                                        Klorane sebo-regulating shampoo “Nettle”                                     When analyzing the range of antiseborrheic  products by the 
                                          for oily hair, 400 ml (Pierre Fabre Lab.                                   drug form, it has been found that shampoos were 78.5%, soap 
                                                      Klorane, France)                                               – 6.95%, oils – 4.2%, pastes – 3.5%, lotions – 2.1%, balsam 
                   Burdock, calamus, Klorane oily dandruff shampoo with Myrtle                                       conditioners  –  1.4%. Products in the form of tablets and 
                     nettle, lovage,   extract, 200 ml (Pierre Fabre Lab. Klorane,              c
                                                                                                ti
                          hops                                                                  i                    ampoules were 0.7% of the total number.  
                                                           France)                              ur
                                                                                                pr                   Ketoconazole and zinc  pyrithione (Head and shoulders, 
                                                                                                nti
                                                                                                a                    Freederm-zink, Syoss, etc.) have been the most widely used 
                                       Klorane dry dandruff hair shampoo with the               , 
                                                                                                e
                                                                                                v
                                          extract of common nasturtium, 200 ml                  ti                   drugs in the treatment of seborrhea. As a rule, the use of 
                                                                                                a
                                            (Pierre Fabre Lab. Klorane, France)                 r
                                                                                                ne                   shampoos containing tar and exfoliating agents has not been 
                                                                                                e
                                                                                                g
                                         Phyto Phytosquam intensive antidandruff                e                    very effective in a long-lasting process since they have had no 
                                                                                                , r
                                       shampoo, 100 ml (Phytosolba Lab., France)                y
                                                                                                tor                  effect on the pathogenic flora, and when changing the shampoo, 
                                                                                                a
                                         Phyto Phytosquam antidandruff cleansing                m                    dandruff appeared again. Keto plus shampoo (Glenmark 
                                                                                                m
                                                                                                a
                                        shampoo,100 ml (Phytosolba Lab., France)                l
                                                                                                nf                   Pharmaceuticals Ltd., India) is a combined drug that contains 
                                                                                                i
                                                                                                -
                                                                                                nti                  zinc and ketoconazole, in this way it can be referred as both 
                                         Weleda Weizen Schuppen-Shampoo, 190                    A
                    Sage, violet, oats         ml (WELEDA AG, Germany)                                               drugs and parapharmaceuticals used for prophylactic purposes. 
                                                                                                                     PP and PMC have been objectively characterized by duality: 
                       Inula, nettle,   ESTEL BHL 63 antidandruff hair tonic, 100                                    they have been additional components of the treatment and 
                   chamomile, calamu            ml (Natura Siberica, Russia)                                         prevention of dandruff, and can regulate the biochemical and 
                         rosemary 
                                         Propoline antidandruff shampoo for oily                                     physiological  processes in the body –  thereby provide the 
                                                                                                                     therapeutic effect [1, 8]
                    Cedar, propolis        hair with cedar and propolis, 250 ml                                                                   . Sometimes, it has been possible to draw 
                                                      (Apivita, Greece)                                              a clear line between PP, PMC and drugs (Figure 2).  
                      Thyme, sage,       Insight antidandruff cleansing lotion, 100 
                        rosemary                      ml (ELEY, Italy) 
                  78                                                                         Journal of Advanced Pharmacy Education & Research  | Apr-Jun 2019 | Vol 9 | Issue 2               
                   
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...The market analysis of antidandruff agents in ukraine alla nemchenko viktoriya nazarkina vitoriia mishchenko sergiy timofeyev maria podkolzina lebedyn national pharmaceutical university department economics pharmacy kharkiv correspondence victoriia ivanovna valentinivska street e mail viktoriamischenko ukr net abstract domestic antiseborrheic medicated products has been conducted a range medicinal cosmetics parapharmaceutical and foreign production registered analyzed terms active substances drug forms as well their affordability data state register medicines price lists official sources specialized information were used according to atc classification most drugs referred derivatives imidazole triazole contain ketoconazole composition da c number was total among with action consisted cosmetic based on plant extracts form shampoos have represented at widely results study it determined that for treating dandruff mainly included antifungal selenium disulfide terbinafine keratolytics salic...

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