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The market analysis of antidandruff agents in Ukraine
Alla Nemchenko, Viktoriya Nazarkina, Viкtoriia Mishchenko*, Sergiy Timofeyev, Maria
Podkolzina, Alla Lebedyn
National Pharmaceutical University, Department of Economics of Pharmacy, Kharkiv, Ukraine.
Correspondence: Victoriia Ivanovna Mishchenko, Department of Economics of Pharmacy, National University of Pharmacy, Kharkiv, Ukraine, 4, Valentinivska Street,
61121, Ukraine. E-mail: viktoriamischenko @ ukr.net
ABSTRACT
The analysis of domestic market of antiseborrheic medicated products has been conducted. A range of products of medicinal cosmetics,
parapharmaceutical products, antidandruff agents of domestic and foreign production registered in Ukraine has been analyzed in terms
of active substances and drug forms, as well as their affordability. In the analysis, the data of the State Register of Medicines, price lists
and official sources of the specialized information were used. According to the ATC classification, most drugs (55%) referred to
derivatives of imidazole and triazole and contain ketoconazole in their composition (D01A C08). The number of antidandruff
medicines registered in Ukraine was 7% of the total number of the products analyzed. Among the products of medicinal cosmetics
with the antiseborrheic action, 50% of the range were consisted of domestic cosmetic agents based on plant extracts. Antiseborrheic
medicated products and products of medicinal cosmetics in the form of shampoos have been represented at the pharmaceutical market
most widely. According to the results of the study, it has been determined that drugs for treating dandruff mainly included antifungal
drugs (ketoconazole, selenium disulfide, terbinafine), keratolytics (salicylic acid, sulfur), keratinization regulators (zinc pyrithione) in
their composition.
Keywords: dandruff, drugs, marketing analysis, parapharmaceutical products, products of medicinal cosmetics, seborrhea.
complex scientifically based approach to be solved [5, 6]
Introduction .
At the same time, one of the key elements is the settlement of
Dandruff (Lat. pityriasis – bran) has often been considered as a the issue of the official status for parapharmaceutical products
cosmetic defect, and at the same time, it is the manifestation of (PP) and products of medicinal cosmetics (PMC) in Ukraine.
a number of dermatological diseases, such as seborrheic According to the current legislation (the Order of the Ministry
[1, 2]
dermatitis, psoriasis, pityriasis versicolor . In recent years, of Health of Ukraine dated 06.07.2012 №. 498 as amended by
there have been high growth rates in the market of antidandruff the order of the Ministry of Health of Ukraine dated
agents (both cosmetic and therapeutic); and it has been 23.11.2015 № 764), the list of goods that can be purchased and
explained not only by an objective necessity due to the sold by pharmacies and their structural subdivisions has been
prevalence of the disease, but also by extensive advertising. The expanded. In recent years, on the shelves of pharmacies there
unsystematic and uncontrolled self-treatment is often has been a large variety of therapeutic shampoos created taking
ineffective and can lead to serious consequences [3, 4]
. Thus, this into account the characteristics of dandruff, and the type and
problem is both cosmetic and medical; moreover, it requires a the condition of hair (dry, normal, oily, painted, etc.). In most
Access this article online cases, the treatment should be prescribed by a specialist-
trichologist or dermatologist.
Website: www.japer.in E-ISSN: 2249-3379 Some shampoos and cosmetics that contain medicinal substances
(for example, ketoconazole, zinc pyrithione), but are not
officially registered in the State Register of Medicines, can be
How to cite this article: Alla Nemchenko, Viktoriya Nazarkina, Viкtoriia sold not only in pharmacies, but also in supermarkets, shops,
Mishchenko, Sergiy Timofeyev, Maria Podkolzina, Alla Lebedyn. The market markets; however, in this case, they have to meet other
analysis of antidandruff agents in Ukraine. J Adv Pharm Edu Res 2019;9(2):75- requirements [7] .
81. .
Source of Support: Nil, Conflict of Interest: None declared.
This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-Non Commercial-
ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is
given and the new creations are licensed under the identical terms.
© 2019 Journal of Advanced Pharmacy Education & Research | Published by SPER Publication 75
Alla Nemchenko et al.: The market analysis of antidandruff agents in Ukraine
The aim of the work was to analyze the market of therapeutic • oily seborrhea is characterized by the increased oiliness
and preventive antidandruff products sold in pharmacies of of hair and scalp due to hyperfunction of the sebaceous
Ukraine in order to provide the effective and controlled glands, as well as yellow scales of dandruff;
dandruff correction and prevention [7].
• mixed seborrhea – simultaneous manifestation of dry
and oily seborrhea on different parts of the head [2, 10]
Materials and Methods .
The market analysis of antiseborrheic products was conducted. Dandruff should be treated differentially. To obtain a reliable
In the study, the data of the State Register of Medicines, papers effect, it is important to have a correct diagnosis from a doctor,
in scientific journals, price lists and information from the official know the causes of the disease, and choose the appropriate set
websites of manufacturers and distributors of products of of measures. As a rule, the duration of treatment is 3-6 weeks.
medicinal cosmetics, and the range of pharmacies in Kharkiv Modern methods of seborrhea treatment have been based on
were used. The methods of comparison, as well as logical, the data confirming its fungal origin. When the scalp shampoos
mathematical and statistical methods were applied. containing ketoconazole, zinc, and tar are prescribed at least
twice a week to eliminate the manifestations of seborrhea, their
Results and Discussion use should be not less than a month. Furthermore, these
products can be used as preventive ones. In severe diseases
Seborrhea is a common dermatological disease that affects the characterized by the presence of lesions with a marked
scalp; its characteristic manifestation is inflammation and flaking inflammation and dense layering of scales before using
of the skin (dandruff). Numerous clinical and laboratory studies antifungal drugs, it is necessary to apply exfoliating products
have confirmed that the main cause of seborrheic dermatitis of (salicylic acid, tar preparations) or to soften the scales with oils,
the scalp and dandruff are yeast-like fungi –Malassezia furfur and then use a shampoo with ketoconazole. In the most severe
(Pityrosporum ovale), which are permanent inhabitants of the skin cases, hormonal ointments are locally prescribed, and antifungal
of a healthy person. Under unfavorable conditions for the drugs are orally administered (ketoconazole, terbinafine,
organism (stress, hormonal imbalance, chronic diseases, fluconazole). The complex therapy includes vitamins, anti-
thermal effects), the protective function of the skin is disturbed; allergic medicines, and drugs for normalization of the
as a result, the opportunistic pathogenic microflora is activated gastrointestinal tract. Measures against dandruff also include
and intensely proliferated causing dandruff [8, 9] normalization of the diet and the water-salt balance restoration.
. The physiotherapeutic procedures, such as cryomassage with
There are the following types of seborrheic dermatitis: liquid nitrogen and darsonvalization of the scalp skin, are also
• dry seborrhea develops as the skin and hair dryness, a recommended [5, 9, 10]
lot of dandruff and severe itching caused by .
hypofunction of the sebaceous glands of the scalp; Currently, all antidandruff agents sold in pharmacies have been
conventionally divided into four groups (Figure 1) [7, 11]
.
I Antimycotics (ketoconazole, climbazole) – inhibit II Antifungals (cyclopirox, zinc pyrithione, octopirox)
development of fungi, improve the hair growth (Nizoral, – affect fungi (Sebiprox, Stiprox, Freederm Zink);
Perkhotal, Ketozoral®-Darnitsa)
Antidandruff
agents
IV Anti-inflammatory agents and revitalisants (plant
III Exfoliating agents (sulfur, salicylic acid) – provide extracts, essential oils) – stabilize the process of cell
removal of dandruff scales from the scalp (Sulsena); division, sooth irritation and itching, contribute to pore
contraction, reduce the activity of sebaceous glands
(Algopix)
Figure 1. Classification of antidandruff agents
As a result of the analysis of the nomenclature of antidandruff • keratolytics (salicylic acid, papain, glycolic acid,
agents by the composition of active substances, it has been keluamide);
found that the main active ingredients were: • keratinization regulators (zinc pyrithione, selenium
• antifungal and antimycotic drugs (ketoconazole, disulfide, octopirox, cyclopirox, ichthyol, tar, sulfur);
terbinafine, clotrimazole, climbazole, miconazole, • cytostatic drugs (selenium disulfide, zink);
cyclopiroxolamine); • antipruritic drugs (extracts of medicinal plants);
76 Journal of Advanced Pharmacy Education & Research | Apr-Jun 2019 | Vol 9 | Issue 2
Alla Nemchenko et al.: The market analysis of antidandruff agents in Ukraine
• anti-inflammatory agents (essential oils, Clear antidandruff shampoo
cyclopiroxolamine) [11, 12]
. and conditioner for men, Unilever, Ukraine
deep cleansing
At the same time, the products of medicinal cosmetics Estel BHL 61 antidandruff
presented at the market can have a mono-component shampoo 250 ml LLC “Unicosmetic”
composition and the targeted action (Table 1) or contain a
complex of active ingredients and, consequently, a wide range Fitoval Regular Care
of action (Table 2). Antidandruff Shampoo КРКА, Slovenia
Formula, 200 ml
Table 1: The analysis of monocomponent products for the Fitoval Intensive Care
treatment of dandruff by the composition of active Antidandruff Shampoo КРКА, Slovenia
Formula, 100 ml
substances Freederm Zink antidandruff
Composition The name and the drug form Manufacturer, country shampoo for dry hair 150 ml Mipharm S.p.A., Italy
Antifungal and antimycotic drugs
Dermazol® shampoo, 20 mg/ml, 50 ml or Kusum Healthcare Ducray Squanorm dry
100 ml, in vials, sachet, 8 ml Pvt. Ltd., India dandruff hair shampoo, 200 Ducray Lab., Freance
ml
Ketozoral®-Darnitsa shampoo, 20 mg/g, 60 Darnitsa, Ukraine
g, 100 g, in vials Freederm tar antidandruff
Pharma International shampoo for oily hair, 150 Mipharm S.p.A., Italy
Kenazol® shampoo, 2%, 100 ml, in vials Jordan ml
Nizoral® shampoo, 20 mg/g, 25 ml, 60 ml, McNeil Products TL “Home Doctor” “Tar +
in bottles Limited tea tree” antidandruff cream RPA “Elfa”, Ukraine
paste, 150 ml
Ebersept shampoo, 60 ml, 120 ml, in vials Bros Ltd, Greece
ole Recipes of Grandmother
z Sebozol antidandruff shampoo, 100 ml Dionis, RF r
ona Ta Agafia. Black antidandruff Natura Siberica, Russia
toc Antidandruff shampoo with ketoconazole, shampoo, 350 ml
Ke 100 ml RPA “Elfa”, Ukraine
ENJEE tar hair shampoo, Beauty and health. Ltd.,
Antidandruff shampoo with ketoconazole LLC “Aromat”, 250 ml Ukraine
100 ml Ukraine “Elfa Horse line” tar
Biocon “Strength of Hair” antidandruff Biocon antidandruff shampoo, 200 RPA “Elfa”, Ukraine
shampoo 150 ml ml
“Horse Power” antidandruff shampoo with Sulsena antidandruff
ketoconazole, 250 ml vial LLC “LekoPro” shampoo, 150 ml
Denon antidandruff, antifungal and hair loss Sulsena antidandruff
ZEE Lab., India e preventive paste, 1% and “Amalgameluxe” Ltd.,
shampoo, 100 ml id
f
l
u 2%, 40 ml, 75 ml Ukraine
is
o ne Sebiprox shampoo, 1%, 60 ml Stiefel Lab., Ireland d
ir i m
p m iu
o
l Stiprox antidandruff therapeutic shampoo, n Sulsena antidandruff peeling
e
yc Stiefel Lab., Ireland l
C xola e shampoo, 150 ml
1.5%, 100 ml S
VICHY Dercos antidandruff
ne Terbinakod shampoo and shower gel for Cosmetic Active Intern.,
i
f PhytoBioTechnologies shampoo for dry hair, 200
na prevention of dandruff and seborrheic France
i ml
b Ltd., Ukraine
r dermatitis, 200 ml
Te
Keratolytics Multicomponent antidandruff agents are aimed at solving a set
c of problems, namely the improvement of the epidermal barrier
i
yl id CM Ultrasensitive gel
c c
i
l a RPA “Elfa”, Ukraine state, cleansing the scalp and hair from skin pells, oily skin and
a
S shampoo, 400 ml hair reduction, and reduction of itching and skin sensitivity. The
Keratinization regulators use of the complex of plant extracts and essential oils of
Skin-cap aerosol, 0.2%, 100 Cheminova Internacional cypress, juniper, rosemary, eucalyptus, tea tree has been rather
ml, in monoblock can S.A., Spain effective since they have the antifungal, anti-inflammatory and
one antipruritic effect, and inhibit the division of keratinocytes [5, 13]
i Nature. MED. antidandruff
th (Table 2).
i Georg BioSystems, Ukraine
r
y shampoo for men, 200 ml
p
nc Clear antidandruff shampoo
Zi
for women, oily scalp Unilever, Ukraine
balance
Journal of Advanced Pharmacy Education & Research | Apr-Jun 2019 | Vol 9 | Issue 2 77
Alla Nemchenko et al.: The market analysis of antidandruff agents in Ukraine
Table 2: The analysis of complex products for the treatment Insight antidandruff cleansing shampoo,
of dandruff 1000 ml (ELEY, Italy)
Composition The name and the drug form Action
l, Hemp oil, clove, Cannaderm Capillus antiseborrheic hair
Selenium disulfide VICHY Dercos antidandruff shampoo for a shampoo, 150 ml (Simply You
normal and oily hair, 200 ml (Cosmetic ung grapefruit Pharmaceuticals A.S)
and salicylic acid f c
Active Internationale, France) nti ti
, a toly nt,
c a Piroctone olamine e
Zinc pyrithione, ti r Kallos Med Detox antidandruff shampoo for
ta e
Alphakeptol D.S. antidandruff shampoo k salicylic acid, olli
piroctone olamine tos oily hair and scalp, 1000 ml (Kallos m
(Laboratoire Dermophil Indien, France) horsetail, lemon e
salicylic acid Cy Cosmetics, Hungary) ,
balm, nettle y
tor c
Dermazol plus shampoo, 50 ml, 100 ml a ti
m i
vials (Kusum Healthcare Pvt. Ltd.) m ur
Ketoconazole, zinc a
Piroctone olamine l pr
nf
pyrithione Keto plus shampoo, 60 ml, 150 ml i nti
fir, nettle, Natura Siberica NS antidandruff hair - a
(Glenmark; India) chamomile, shampoo, 400 ml (Natura Siberica, Russia) nti
l, a
wormwood, a
Eucerin DermoCapillare antidandruff gel junipe ung
Piroctone olamine c f
shampoo for oily scalp, 250 ml (Beiersdorf ti nti
climbazole ta Piroctone olamine, DUCRAY Squanorm oily dandruff hair A
AG, Germany) tos glycolic acid shampoo, 200 ml
y
c
,
c
i
Ducray Kertyol P.S.O. Keratoreducing t , e
c v
TL “Green Pharmacy”. “Birch buds and i i
t t
Cream, 100 ml (France) toly Piroctone olamine i a
a ur
r castor oil” antidandruff shampoo, 350 ml er
e birch buds, castor o pr en
Ducray Selegel dry dandruff shampoo, 125 l, k (RPA “Elfa”, Ukraine) nti eg
Salicylic acid, a A r
cyclopiroxolamine, ml (Pierre Fabre Dermo-Cosmetique, ung
f
zinc pyrithione France) nti Tar and salicylic Algopix antidandruff shampoo, 200 g
A c
acid (Medica АТ, Bulgaria) ti
Kallos KJMN antidandruff shampoo 1 L toly
a
(Kallos Cosmetics, Hungary) Pharma Bio tar antidandruff shampoo, 200 r
Sulfur and tar Ke
ml (Alliance of beauty, Ukraine)
Climbazole and Zinovit antidandruff and anti-inflammatory
l
shampoo, 150 ml (ZAO Zelenaya Dubrava, Sulphide1% + Saw “Elfa” Sulsen_forte antidandruff shampoo, a
zinc pyrithione Russia) 2%, for oily hair, 150 ml (RPA “Elfa”, ung
Palmetto1% f
Bio Pharma Burdock antidandruff shampoo, Ukraine) nti
A
200 ml (Alliance of beauty, Ukraine)
l
Sulphide1% + “Elfa” Sulsen_forte antidandruff shampoo, a
Klorane dry dandruff shampoo with the 2%, for normal and dry hair, 150 ml (RPA ung
extract of Nasturtium, 200 ml (Pierre Fabre Aminotein1% f
“Elfa”, Ukraine) nti
Lab. Klorane, France) A
Klorane sebo-regulating shampoo “Nettle” When analyzing the range of antiseborrheic products by the
for oily hair, 400 ml (Pierre Fabre Lab. drug form, it has been found that shampoos were 78.5%, soap
Klorane, France) – 6.95%, oils – 4.2%, pastes – 3.5%, lotions – 2.1%, balsam
Burdock, calamus, Klorane oily dandruff shampoo with Myrtle conditioners – 1.4%. Products in the form of tablets and
nettle, lovage, extract, 200 ml (Pierre Fabre Lab. Klorane, c
ti
hops i ampoules were 0.7% of the total number.
France) ur
pr Ketoconazole and zinc pyrithione (Head and shoulders,
nti
a Freederm-zink, Syoss, etc.) have been the most widely used
Klorane dry dandruff hair shampoo with the ,
e
v
extract of common nasturtium, 200 ml ti drugs in the treatment of seborrhea. As a rule, the use of
a
(Pierre Fabre Lab. Klorane, France) r
ne shampoos containing tar and exfoliating agents has not been
e
g
Phyto Phytosquam intensive antidandruff e very effective in a long-lasting process since they have had no
, r
shampoo, 100 ml (Phytosolba Lab., France) y
tor effect on the pathogenic flora, and when changing the shampoo,
a
Phyto Phytosquam antidandruff cleansing m dandruff appeared again. Keto plus shampoo (Glenmark
m
a
shampoo,100 ml (Phytosolba Lab., France) l
nf Pharmaceuticals Ltd., India) is a combined drug that contains
i
-
nti zinc and ketoconazole, in this way it can be referred as both
Weleda Weizen Schuppen-Shampoo, 190 A
Sage, violet, oats ml (WELEDA AG, Germany) drugs and parapharmaceuticals used for prophylactic purposes.
PP and PMC have been objectively characterized by duality:
Inula, nettle, ESTEL BHL 63 antidandruff hair tonic, 100 they have been additional components of the treatment and
chamomile, calamu ml (Natura Siberica, Russia) prevention of dandruff, and can regulate the biochemical and
rosemary
Propoline antidandruff shampoo for oily physiological processes in the body – thereby provide the
therapeutic effect [1, 8]
Cedar, propolis hair with cedar and propolis, 250 ml . Sometimes, it has been possible to draw
(Apivita, Greece) a clear line between PP, PMC and drugs (Figure 2).
Thyme, sage, Insight antidandruff cleansing lotion, 100
rosemary ml (ELEY, Italy)
78 Journal of Advanced Pharmacy Education & Research | Apr-Jun 2019 | Vol 9 | Issue 2
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