A.N.U.  B.PHARMACY  SYLLABUS  (WITH EFFECT FROM  2008 - 09  ACADEMIC YEAR)
                          III/IV  B.PHARMACY  (5th Semester)
                 501  PHARMACEUTICAL CHEMISTRY-IV  (MEDICINAL–II)
                                   (Theory)  (75 hrs.)
           Unit  :  01
           Quantitative structure activity relationship (QSAR) studies, basic concepts  of
           computer   aided   drug   design,   different    drug  design  approaches,  basic
           concepts of combinatorial synthesis.
           Unit  :  02
           General Anaesthetics : Introduction, classification, mechanism of action,
           synthesis   and   therapeutic   uses  of    halothane,   ketamine,  methohexital.
           Local Anaesthetics : Introduction, chemical classification, ideal requirements,
           mode of action, SAR, structures of important local anaesthetics,    metabolism
           and   synthesis of  benzocaine, procaine, lidocaine, tetracaine and cinchocaine.
           Hypnotics  and  Sedatives – SAR of barbiturates,  synthesis, metabolism and
           therapeutic uses of  phenobarbital, amylobarbital, pentobarbital,  cyclobarbitone
           calcium, thiopental,  hexobarbital.  chlordiazepoxide, diazepam, alprazolam.
           Anti-psychotics –  SAR of phenothiazines, synthesis and therapaeutic uses  of
           promethazine, Prochlorperazine, Fluphenazine,  chlorpromazine, haloperidol,
           clozapine, oxypentine.
           Anti– depressants:  Synthesis and therapaeutic uses  of amitryptaline, doxepine,
           iproniazid, isocarboxizide, trazodone, fluoxetin
           Anti – Anxietyagents : Synthesis and therapaeutic uses  of nitrazepam,
           lorazepam, prazepam
           Anti-epileptics – Synthesis and therapaeutic uses  of  phenytoin, valproic acid,
           carbamazepine, ethosuximide.
           Unit  :  03
           Drugs affecting adrenergic mechanism : Adrenergic receptors, biosynthesis  of
           catecholamines,   chemical   classification   along   with   structures,   S.A.R of
           adrenergic   drugs,   adrenergic  agonists,  adrenergic  blockers.   Synthesis
           and therapeutic uses of   phenylephrine, ephedrine,  naphazoline,   terbutaline,
           dopamine, amphetamine, phenoxybenzamine,  propranolol, metaprolol, atenolol,
           tolazoline.
           Drugs affecting  cholinergic mechanism:   Introduction,     SAR,    cholinergic
           receptors, study of cholinergic agonists, indirectly acting cholinergic  agonists,
           cholinergic    blocking  agents,  neuromuscular  blocking  agents. Synthesis and
           therapeutic uses of    methacholine,     carbachol,      neostigmine,      pralidoxime,
           propantheline, dicyclamine, tropicamide, atropine, bipyridine.
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        A.N.U.  B.PHARMACY  SYLLABUS  (WITH EFFECT FROM  2008 - 09  ACADEMIC YEAR)
         Unit  :  04
         Cardiovascular Agents: Introduction,   classification, mechanism of action of
         antianginal   agents,   calcium   channel  blockers,   Anti-arrhythmic   drugs,
         antihypertensive   agents,   antihyperlipidemic  agents   and   anticoagulants.
         Synthesis    and   therapeutic  uses  of    methyldopa,   amlodipine, clonidine,
         hydralazine,   verapamil,   clofibrate,   dicoumorol, warfarin
         Hypoglycaemics : General account on   pancreatic  malfunctions.    chemical
         classification,   S.A.R of hypoglycemics, Insulin preparations, a  brief   account
         on   statin    antidiabetics –   phenformin,  glipizide,  chlopropamide,  including
         a  brief  account  on  PPARγ  inhibitors,  meglitinide   analogues, α-glucosidase
         inhibitors–Acarbose,   miglitol.    A  brief  account  on  thyroid  and  antithyroid
         drugs.
         Unit  : 05
         Opoid Analgesics : Classification along with structures, mechanism of  action,
         S.A.R of opioid analgesics, mixed agonists and mixed antagonists,  central and
         peripheral acting anti tussive agents.  Structure and therapeutic uses  of
         morphine,   codeine,   diacetylmorphine,   nalorphine,   levalophan, noscapine,
         dextromethorphan.
         NSAIDS   (Non-steroidal   anti-inflamatory   agents)  :   Introduction and types
         of   pain   and   inflammation.   Synthesis, metabolism and therapeutic uses of
         aspirin,   paracetamol,    ibuprofen, mefenamic  acid,   diclofenac,   piroxicam.
         A    brief    account    on    Cox-2 inhibitors.
         Unit  :  06
         DIURETICS  :   Introduction,   chemical   classification  along with structures,
         mechanism  of  action,  S.A.R,   metabolism  and  synthesis  of acetazolamide,
         benzthiazide, furosemide, ethacrynic acid chlorthiazide, hydrochlorthiazide
         and amiloride.
         Antihistaminic agents : Introduction,  histamine  receptors,  biosynthesis  of
         histamine, study of H1 and H2 antagonists.    Chemical   classification   along
         with  structures,  mechanism  of action, S.A.R,  of antihistamines.   Synthesis
         and metabolism of  diphenhydramine,  pyrilamine, mepyramine, cyclizine
         pheninramine, promethazine, antazoline, astimizole, cetrizine,  cimetidine.
         Diagnostic agents :  Introduction,  structures and therapeutic  uses  of  some
         important organic compounds   as   diagnostic  agents.    Synthesis of iopanoic
         acid, fluorescein, diatriazoic acid and metyrapone
                               :: 54 ::
              A.N.U.  B.PHARMACY  SYLLABUS  (WITH EFFECT FROM  2008 - 09  ACADEMIC YEAR)
                                   III/IV  B.PHARMACY  (5th Semester)
                              502   PHARMACEUTICAL CHEMISTRY–IV
                                (MEDICINAL-II)  (Practicals)  (75 hrs.)
              01*. Assay of indomethacin capsules – I.P.
              02*. Assay of glipizide/frusemide tablets – I.P.
              03*. Assay of ibuprofen suspension – I.P.
              04*. Assay of paracetamol elixir/tablet – I.P.
              05. Assay of ascorbic acid tablets – I.P.
              06*. Assay of salicylic acid ointment – I.P.
              07*. Assay of aminophylline injection -  I.P.
              08. Assay of metronidazole tablets – I.P.
              09*. Synthesis of benzil from benzoin
              10. Synthesis of benzillic acid from benzil
              11. Synthesis of 7-hydroxy 4-methyl coumarin
              12. Synthesis of benzimidazole
              13*. Synthesis of benzocaine
              14*. Synthesis of benzotriazole
              15. Synthesis of aspirin
              16*. Synthesis  of phenytoin (5, 5’ – diphenyl hydantoin)
              17. Synthesis of sulphanilamide.
              TEST  BOOKS
              1. Text book of Medicinal Chemistry by William O. Foye, Lea Febiger,
                  Philadelphia.  Wilson & Giswold’s Text book of organic Medicinal Chemistry
                                                                                      th
                  and pharmaceutical chemistry by JH Block & JM Beale (Eds), 11  Ed, Lipcott,
                  Raven, Philadelphia, 2004.
              2. D. Abraham (Ed), Burger Medicinal chemistry ad Drug discovery, Vol. 1 & 2.
                  John Wiley & Sons, New York 2003, 6th Ed.
              3. Lippincott Williams and   Wilkins:   Remington   Pharmaceutical Sciences;
                  20th Edition.
              4. Bentley and Driver’s Textbook of Pharmaceutical Chemistry Ed: l.     M.
                  Atherden. Oxford University Press, Delhi.
              5. B.N. Lads, MG.Mandel and F.I. way, Fundamentals of drug metabolism &
                  disposition, William & welking co, Baltimore USA.
              6. Hansch, Comprehensive medicinal chemistry, Vol 1 – 6 Elsevier pergmon
                  press, Oxford
              7. Rama Rao Nadendla,   Principles of Organic Medicinal chemistry, Vol-I,
                  New-Age International Publishers Pvt., limited, New Delhi,  2005
              8. Daniel lednicer, Strategies For Organic Drug Synthesis And Design, John
                  Wiley, N. Y. 1998.
              9. D. Lednicer, Organic drug synthesis, Vol, 1 – 6, J.Wiley N.Y.
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             A.N.U.  B.PHARMACY  SYLLABUS  (WITH EFFECT FROM  2008 - 09  ACADEMIC YEAR)
                                                           th
                                  III/IV  B.PHARMACY  (5  Semester)
                                       MODEL QUESTION PAPER
                   501  PHARMACEUTICAL CHEMISTRY-IV (MEDICINAL-II) (Theory)
              Time :   3 hours                                       Max.Marks : 80
                                               SECTION-A
             Answer any four questions                         (4 X 10 = 40 marks)
             1.   Add a note on different drug design approaches.  Give a detailed
                  account of computer aided drug design.
             2.   Classify sedatives and hypnotics  with suitable  examples. Write
                  the SAR and mode of action of Barbiturates.
             3.   Outline the chemical classification of adrenergic drugs. Discuss
                  their mode of action and SAR.
             4.   What are oral hypoglycemic agents ? Classify them with examples
                  and write their mode of action.
             5.   Classify the non-steroidal anti inflammatory agents with examples and
                  discuss their mode of action ? How do you synthesize diclofenac and
                  piroxicom ?
             6.   Classify H1 antagonists with examples ? Discuss the SAR and
                  mechanism of action of these drugs.
                                              SECTION - B
             Answer any TEN questions                          (10 X 4 = 40 marks)
             7.   Write short notes on Free Wilson analysis
             8.   Short notes on descriptors used in QSAR
             9.   Outline the synthesis and therapeutic uses of phenytoin.
             10. Mechanism of action of MAO inhibitors.
             11. Short notes on cholinergic receptors.
             12. Give the synthesis and  mechanism of propantheline.
             13. Write short notes on antianginal agents.
             14. Outline the synthesis of clonidine
             15. Discuss the mode of action of opioid analgesics
             16. Short notes on opioid antagonists
             17. Write the SAR and mode of action of thiazide diuretics.
             18. Add a note on synthesis and metabolism of cetrizine.
                                                           th
                                  III/IV  B.PHARMACY  (5  Semester)
                                  MODEL QUESTION PAPER (Practicals)
                       502  PHARMACEUTICAL CHEMISTRY-IV (MEDICINAL-II)
              Time :   4 hours                                       Max.Marks : 80
             1.   Synopsis            :    10 Marks
             2*.  Major Experiment    :    35 Marks
             3.   Minor Experiment    :    20 Marks
             4.   Viva-Voce           :    15 Marks
                                           -------------
                                 Total:    80 Marks
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