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FNH 451 Nutrient Metabolism and Implications for Health
Winter Session, Term 1, 2018/2019
Instructor: Dr. Zhaoming Xu Office: FNH 231
Phone: (604) 822-6253 Email: zxu@mail.ubc.ca
Class Time: 9:30 a.m. - 11:00 a.m., Tuesdays and Thursdays
Classrooms: All class activities and group presentations are in MCML 358
All group activities are in assigned classroom: MCML 360B (Group 1),
360D (Group 2), 360F (Group 3), 360H (Group 4), 360K (Group 5), and
360L (Group 6)
Course Description and Objectives
Regulation of nutrient metabolism is a core concept in nutrition, and a balanced regulation
is critical to human health. As a capstone course, the focus of this course is on applying knowledge
learned in basic nutrition, physiology, genetics, and biochemistry to developing a comprehensive
understanding of the metabolic basis of the interactions of nutrients under physiological and
various pathological states.
Guided by this focus, the objectives of this course are to develop and strengthen students'
understanding of metabolic regulation and nutrient-nutrient interactions, and to provide students
with research experience through addressing nutritional questions using current scientific literature.
To achieve these objectives, this course has adopted project-based learning as the mode of delivery.
Students, working in groups, conduct an in-depth research on a given topic and report their
research findings through a formal research report and oral presentation.
Learning Outcomes
Upon the completion of this course, students should be able to:
- Discuss new advances in the area of nutrient metabolism with examples;
- Engage in scientific discussion on the importance of metabolic regulation in
maintaining and promoting health, and the metabolic impact of diseases with
examples;
- Explain nutrient-gene interactions and its impact on nutrient metabolism with
examples;
- Discuss metabolic and health implications of nutrient intakes with examples;
- Integrate knowledge from nutrition, physiology, and biochemistry to address issues in
the area of nutrient metabolism under physiological and physiopathological states;
- Critique original research papers published in peer-reviewed scientific journals in the
area of nutrient metabolism and related areas with a higher level of confidence; and
- Strengthen scientific writing and oral presentation skills.
Pre-requisites
Pre-requisites: BIOC 302, CAPS 301 or equivalent, and FNH 350.
Assistance Available to Students
The FNH 451 Canvas site is an important learning and communication resource for the course,
including the Assignment Guideline. During regular class time, I will join group discussions to
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provide guidance and feedback on your research, and to answer any questions arising from your
research. I will also be available to help with your research during my office hours (11:30 a.m. -
1:00 p.m. on Tuesdays). You are strongly encouraged to take advantage of this designated time to
discuss your research projects on a first-come, first-served basis. In addition, I will also schedule
a one-hour meeting with each group outside of the regular class time and office hours starting
November 6, 2018. The main purpose of these meetings is to provide feedbacks to your group’s
presentation. Please refer to the Activities section below to schedule your group’s meeting.
Course Evaluation
Research Project:
Letter of intent 10%
Oral presentation 30%
Final research report 50%
Participation:
Participation in group presentations - attendance 3%
Participation in group presentations - participation of Q&A 4%
Providing feedback to group members 3%
Research Project
Students will form groups of 7 - 8 students/group to work on a current topic in the general
area of nutrient metabolism and metabolic regulation. Each group will be given a topic by the
instructor. The topic provides a general framework for each group to develop an appropriate
research question, for which each group will conduct its research, prepare a letter of intent, oral
presentation to the class, and a final research report.
Your individual grade on the letter of intent, oral presentation, and final research report
will be calculated by multiplying your group mark by your peer-evaluation-factor (PEF) assigned
to you by your group members. The Guideline for Group Research Projects provides detailed
information on evaluation criteria, weighting, and format requirements for the letter of intent, oral
presentation and final research report, further information on the PEF, and due dates. The
Guideline is available on the course Canvas site.
Participation
You are required to attend and be on time for all student presentations (November 22 - 29,
2018). Attendance at each of the group presentations in class is worth 0.5% of your final grade,
for a total of 3%. Attendance will be taken within the first 10 minutes of the class. If you have a
valid reason for missing class, please contact the instructor BEFORE the class. In the case of
illness, a doctor’s note is required. You are encouraged to actively listen and participate in the
discussion following the presentations. To encourage participation, 4% of your final mark will be
based on your participation in the discussion period following the student presentations.
Providing feedback to group members
Throughout the term you will be working in groups. To encourage communication within
groups, you will be asked to evaluate and provide feedback for yourself, your group and your
group members using the S (strength) - O (opportunity for improvement) - R (remedy) approach.
Your feedback should be posted on your group’s discussion board on the course Canvas site. Your
instructor will check to ensure that you have posted feedback, but will not comment on your
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discussion board. You will be asked to post feedback six times throughout the term, once during
each of the following periods: September 6 - 21, September 24 - October 5, October 8 - 19,
October 22 - November 2, November 5 - 16, November 19 - 30. Each post will be worth 0.5%
of your final grade for a total of 3%. Late or incomplete postings will not be counted.
Academic Misconduct
The integrity of academic work depends on the honesty of all those who work in this
environment and the observance of accepted conventions such as acknowledging the work of
others through careful citation of all sources used in your work. Plagiarism of all forms is treated
as a serious offence at UBC. You should be aware of the sections of the University Calendar
that address academic integrity
(http://www.calendar.ubc.ca/vancouver/index.cfm?tree=3,286,0,0#15620 and
http://learningcommons.ubc.ca/academic-integrity/) and plagiarism
(http://www.calendar.ubc.ca/vancouver/?tree=3,54,111,959). The UBC Library also has a useful
web-based Plagiarism Resource Centre that explains what plagiarism is and how to avoid it
(http://help.library.ubc.ca/planning-your-research/academic-integrity-plagiarism/). If you have
questions or concerns about any of these policies or conventions in relation to how they apply to
the work you do in this course, please discuss them with me.
Activities (Tentative)
Date Location Activities
09/03 Imagine UBC (no class)
09/06 MCML 358 Introduction to the course
Tips for conducting an effective literature research
09/11 - 27 MCML 360B, Group research (in-class in assigned rooms; all groups)
D, F, H, K, & L
09/28 Letter of intent and the peer evaluation form for the
letter of intent are due at 5:00 pm (all groups).
10/2 - 11/20 MCML 360B, Group research (in-class in assigned rooms; all groups)
D, F, H, K, & L
11/06 Group 3 and 5: individual group meeting with Dr. Xu
(meeting time: TBD)
11/08 Group 1 and 2: individual group meeting with Dr. Xu
(meeting time: TBD)
11/13 Group 4 and 6: individual group meeting with Dr. Xu
(meeting time: TBD)
11/22 MCML 358 Group presentation:
- Group 3: Generation and physiological activities of
nonretinoid apocarotenoids in mammals
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- Group 5: Unhealthy gut, unhealthy brain: gut
microbiota and risk of neurodegenerative
diseases
Abstract and slides are due at 5:00 pm on November 15.
11/27 MCML 358 Group presentation:
- Group 1: One-carbon metabolism and arsenic toxicity
- Group 2: How and why transferrin receptor is a target
for viral infection
Abstract and slides are due at 5:00 pm on November 20.
11/29 MCML 358 Group presentation:
- Group 4: Targeting glycemia and insulinemia status for
better personalized dietary management of
overweight and obesity
- Group 6: Impact of nutrient overload on metabolic
regulation
Abstract and slides are due at 5:00 pm on November 22.
11/30 The final research report, and peer evaluation form for
oral presentation and final research report are due at
5:00 pm (all groups).
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