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WHAT COULD LOSING WEIGHT WITH WEGOVY™ LOOK LIKE FOR YOU? SEE PAGE 8 Finally, lose weight and keep it off Actor portrayals throughout. Visit SaveOnWegovy.com to check your cost and coverage. What is Wegovy™? Wegovy™ (semaglutide) injection 2.4 mg is an injectable prescription medicine used for adults with obesity (BMI ≥30) or overweight (excess weight) (BMI ≥27) who also have weight-related medical problems to help them lose weight and keep the weight off. • Wegovy™ should be used with a reduced calorie meal plan and increased physical activity. • Wegovy™ contains semaglutide and should not be used with other semaglutide-containing products or other GLP-1 receptor agonist medicines. • It is not known if Wegovy™ is safe and effective when taken with other prescription, over-the-counter, or herbal weight loss products. • It is not known if Wegovy™ can be used safely in people with a history of pancreatitis. • It is not known if Wegovy™ is safe and effective for use in children under 18 years of age. Please see additional Important Safety Information throughout. Please click here for Prescribing Information, including Medication Guide. Why is it so hard to lose weight and keep it off? There are 2 stages of weight management— losing weight and maintaining weight loss Reducing calories and increasing physical activity may lead to weight loss. But when you lose weight by eating fewer calories, your appetite hormones can change, making you feel more hungry so you eat more. This is L WEIGHT- O S S G why it may be difficult to maintain the weight you’ve lost. O A L S YOU’RE NOT 9 out of 10 adults with ALONE obesity did not maintain weight loss long term YOU START LOSING WEIGHT YOUR BODY PUSHES BACK A reduced-calorie meal plan and But when you lose weight by eating increased physical activity are important fewer calories, your appetite may parts of your weight-loss plan. increase. This can push back against your progress. THE GOOD there are prescription medicines that can help NEWS IS you address the cycle of weight loss and regain. 2 visit Wegovy.com | How does Wegovy™ work? I’m more satisfied after dinner. Every day, the brain receives signals from different I want dessert less often. places in the body. Some of these signals, called appetite hormones, help regulate your food intake. REDUCES APPETITE Wegovy™ works by mimicking a hormone that targets areas of the brain involved in regulating appetite and food intake. This can help you eat less, which can lead to WEIGHT LOSS Actor portrayal. Talk to your health care provider at your next visit. Visit Wegovy.com for tips that Important Safety Information can help you begin a conversation What is the most important information I should know about Wegovy™? Wegovy™ may cause serious side effects, including: Important Safety Information • Possible thyroid tumors, including cancer. Tell What is the most important information I should know your healthcare provider if you get a lump or swelling about Wegovy™? (cont’d) in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of Wegovy™ may cause serious side effects, including: thyroid cancer. In studies with rodents, Wegovy™ and (cont’d) medicines that work like Wegovy™ caused thyroid • Do not use Wegovy™ if you or any of your family have tumors, including thyroid cancer. It is not known if ever had a type of thyroid cancer called medullary Wegovy™ will cause thyroid tumors or a type of thyroid thyroid carcinoma (MTC) or if you have an endocrine cancer called medullary thyroid carcinoma (MTC) in people. system condition called Please see additional Important Safety Information Multiple Endocrine throughout. Please click here for Prescribing Neoplasia syndrome Information, including Medication Guide. type 2 (MEN 2). 44 visit Wegovy.com | Wegovy™ could help you lose weight and keep it off In the same study, in addition to a reduced-calorie meal plan and increased physical activity, people In a 68-week medical study of 1,961 taking Wegovy™ lost more weight vs placebo adults* living with obesity or excess weight with a related medical problem: %of people taking Wegovy™ 5% 83 o vs m r e r ADULTS LOST o % WEIGHT 31 of people taking placebo ON AVERAGE LOSS %of people taking Wegovy™ 10% 66 o m r e r vs o % WEIGHT 12 of people taking placebo (or ~15% body weight) LOSS while taking Wegovy™ • People taking placebo lost an average % of 6 lb (or ~2.5% body weight) 15% 48 of people taking Wegovy™ • The average starting weight for both o vs m r e r groups was ~232 lb o 5%of people taking placebo WEIGHT While taking Wegovy™, people not only lost LOSS weight, but also kept it off. * Results are from a 68-week medical study of adults with obesity (BMI ≥30) and adults with excess weight (BMI ≥27) who also had weight-related medical problems including high blood pressure or high cholesterol. People with type 2 diabetes were excluded. Both groups were instructed to take the medicine along with a reduced-calorie meal plan and increased physical activity. 7% of people taking Wegovy™ (92 people) left the medical study due to side effects, compared to 3.1% of people taking placebo (20 people). Important Safety Information (cont’d) Before using Wegovy™, tell your healthcare provider if you have any other medical conditions, including if you: Important Safety Information (cont’d) • have or have had problems with your pancreas or What is the most important information I should kidneys. know about Wegovy™? (cont’d) • have type 2 diabetes and a history of diabetic retinopathy. • have or have had depression, suicidal thoughts, or Do not use Wegovy™ if: mental health issues. • you or any of your family have ever had a type of thyroid • are pregnant or plan to become pregnant. Wegovy™ may cancer called medullary thyroid carcinoma (MTC) or if harm your unborn baby. You should stop using Wegovy™ you have an endocrine system condition called Multiple 2 months before you plan to become pregnant. Endocrine Neoplasia syndrome type 2 (MEN 2). • are breastfeeding or plan to breastfeed. It is not known • you have had a serious allergic reaction to semaglutide if Wegovy™ passes into your breast milk. or any of the ingredients in Wegovy™. Please see additional Important Safety Information throughout. Please click here for Prescribing Information, including Medication Guide. 66
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