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nutritional emulsifiers and their relation to gut health brecht bruneel msc central technical manager orffa rearing animals in antibiotic at the lipid water interface and help in free systems is ...

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                    Nutritional emulsifiers and 
                    their relation to gut health
                    Brecht Bruneel (MSc), Central Technical Manager, Orffa
                     Rearing animals in antibiotic-                                                                                                at the lipid/water interface and help in 
                     free systems is a challenge. A  the formation of micelles, sphere like 
                     big question is how to deal with  aggregates of fat in water. Bile acid-
                     increased pathogenic pressure  containing micelles augment the activity 
                     and optimise gut health. When  of lipase towards the digestion of lipids. 
                                                                                                                                                   Prior to secretion in the intestine, 
                     disbalanced, the microflora 
                     can have a big impact on conjugation with taurine or glycine takes 
                     the digestibility of nutrients. place in liver cells to form conjugated 
                     Fat digestibility, in particular,  bile acids (Figure 1). Only conjugated 
                     will be affected by bacteria  bile acids are able to act efficiently as an 
                                                                                                                                                   emulsifier. The unconjugated forms are 
                     that impair the function of bile  insoluble in water due to their specific 
                     acids, vital components of the 
                     fat digestibility apparatus. 
                     These bacteria are more pronounced in 
                     disbalanced gastro-intestinal tracts and 
                     are a particular threat when the use of 
                     antibiotics is limited. 
                     Low fat digestibility will imply a loss of 
                     energy, which will not be available for 
                     growth.
                     To counteract this sub-optimal situation, 
                     a nutritional emulsifier can be added 
                     to the diet. This additive does not only 
                     save costs in healthy animals, but also 
                     supports flocks with intestinal health 
                     issues.
                     Bile acids as natural emulsifiers
                     Fat digestion is to a large extent dependent 
                     on bile acids (natural emulsifiers), next 
                     to pancreatic lipase and colipase. Bile 
                     acids, synthesized in liver cells, will act 
                                                      April 2019
                     52
                                                      Expanding horizons                                                                     Africa
                     molecular structure and subsequent acid-                                                                                      The group without antibiotics showed 
                     base properties. They will be excreted in                                                                                     high numbers of Clostridium perfringens 
                     the faeces.                                                                                                                   in the small intestine and lower amounts 
                                                                                                                                                   of conjugated bile acids. Lower amounts                                                                                               Nutrition
                     Some intestinal bacteria are capable  of conjugated bile acids reduced the 
                     of hydrolysing the amide bond and  absorption of fatty acids and fat-soluble 
                     removing glycine and taurine. Clostridium                                                                                     compounds (α-tocopherol). 
                     perfringens, for example, has been shown 
                     to  express  high  levels  of  the  bile  salt                                                                                Lipase activity was also assessed, and 
                     hydrolase enzyme. When hydrolysed, the                                                                                        shown to be decreased in antibiotic-
                     bile salt is in its unconjugated form and                                                                                     free birds, suggesting an effect of the 
                     loses its ability to act as an emulsifier,  conjugated bile salts on the activity of 
                     resulting in decreased fat digestion.                                                                                         lipase.
                     Imbalanced microflora and its effect on                                                                                       The same trend was observed in another 
                     fat digestibility                                                                                                             trial (Table 2). In this study, the effect of 
                     The influence of microbiota, antibiotics  the microbiota on the conjugated bile 
                     and conjugated bile acid concentration  acid status and subsequent fat digestion 
                     on the adsorption of fat was investigated                                                                                     was compared between birds reared in 
                     in broilers (Table 1).                                                                                                        sterilised conditions and conventionally 
                                                                                                                                                   reared birds. Birds reared in sterilised 
                             Table 1: Concentrations in the contents of the proximal part of the small intestine in chickens 
                             and ileal absorption coefficients at day 35 (Knarreborg et al. 2004)
                              Broilers, day 35                                                                                             With antibiotics                                               Without antibiotics
                              Concentrations in the contents of the proximal part of the small intestine
                              Clostridium perfringens (log10 CFU/g                                                                                  a                                                             b
                              digesta)                                                                                                   5.48                                                           7.14
                                                                                                                                                    a                                                             b
                              Conjugated bile acids (µmol/g digesta)                                                                     11.7                                                           8.88
                              Ileal absorption coefficients
                                                                                                                                               a                                                              b
                              Total fatty acid absorption (%)                                                                            82                                                             73
                            a,b
                                 Different superscript shows significant difference between groups (P < 0.05)
                             Table 2: Lipid faecal apparent digestibility (%) in broilers (Maisionnier et al. 2003)
                             Broilers, day 21                                                                            Limited microflora                                                 Conventional microflora
                                                                                                                         (birds reared in sterilized  (conventional reared birds)
                                                                                                                         conditions)
                                                                                                                              a                                                                  b
                           Conjugated bile acids (µmol/g)                                                               17                                                                3,3
                                                                                                                                  a                                                                 b
                           Lipid faecal apparent digestibility (%)                                                      88,9                                                              81,4
                           a,b
                                Different superscript shows significant difference between groups (P < 0.05)
                                                                                                                                                                                                                  April 2019                                    53
                                                                                                                                             Africa                                           Expanding horizons
                EXCENTIA ENE  
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   For more information, please contact our Orffa specialist Jaco Smit or Nicholas Williams via mea@orffa.com
   Engineering your feed solutions
   www.orffa.com
EXCENTIA ENE     Figure 1: Conjugation with taurine or glycine to form a conjugated, active bile salt
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                     conditions showed a higher lipid faecal  An emulsifier with a low HLB is more 
                     apparent digestibility compared to fat soluble (lipophilic) and an emulsifier 
                     conventionally reared birds, confirming  with a high HLB is more water soluble 
                     the negative effect of some bacteria on  (hydrophilic). Due to the fact that an 
                     fat digestion. This can be explained by the                                                                                   animal consumes almost twice as much 
                     difference in concentration of conjugated                                                                                     water as feed, the intestine is a very 
                     bile salts.                                                                                                                   watery environment. The goal of a 
                                                                                                                                                   nutritional emulsifier is to optimise the 
                     The need for a nutritional emulsifier                                                                                         emulsification and micelle forming in 
                     Fat digestion is influenced by many factors                                                                                   the intestine and therefore an emulsifier 
                     (e.g. fat source, age). Less attention  with a high HLB (hydrophilic) is most 
                     is given to the effect of the microflora.  preferred.
                     However, considering the findings of  Conclusion
                     the studies and literature work stated 
                     above, it should be an important factor  A disbalanced microflora has an 
                     to consider.                                                                                                                  important negative effect on fat 
                                                                                                                                                   digestibility. To counteract this, the 
                     Nutritional emulsifiers aim to reach  activity of a nutritional emulsifier should 
                     maximal  potential  in  the  intestinal                                                                                       be considered. A nutritional emulsifier 
For more information, please contact our Orffa specialist Jaco Smit or Nicholas Williams via mea@orffa.comenvironment and improve fat digestion.   with a proven ability to increase fat 
                                                                                                                                                   digestion is important in a healthy broiler, 
                     A parameter to choose the optimal  but crucial in a pathogen challenged bird.
                     emulsifier for every specific application 
                     is HLB (hydrophilic-lipophilic balance).  *References available on request Africa 
Engineering your feed solutions
                                                                                                                                                                                                                  April 2019                                    55
www.orffa.com                                                                                                                                Africa                                           Expanding horizons
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...Nutritional emulsifiers and their relation to gut health brecht bruneel msc central technical manager orffa rearing animals in antibiotic at the lipid water interface help free systems is a challenge formation of micelles sphere like big question how deal with aggregates fat bile acid increased pathogenic pressure containing augment activity optimise when lipase towards digestion lipids prior secretion intestine disbalanced microflora can have impact on conjugation taurine or glycine takes digestibility nutrients place liver cells form conjugated particular acids figure only will be affected by bacteria are able act efficiently as an emulsifier unconjugated forms that impair function insoluble due specific vital components apparatus these more pronounced gastro intestinal tracts threat use antibiotics limited low imply loss energy which not available for growth counteract this sub optimal situation added diet additive does save costs healthy but also supports flocks issues natural larg...

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